Carbonic anhydrase VI.

Abstract

Carbonic anhydrase VI is the only secreted human carbonic anhydrase, identified in saliva, milk, colostrum, in the esophagus and in different parts of the GI tract, in the upper respiratory tract, in lacrimal glands, in serum and in other parts of the human body. The chapter provides a detailed overview of its structure, activity, physiological and pathological roles of CA VI and of its susceptibility to different classes of inhibitors and activators used to modulate its activity.