Effectiveness of Sensorimotor and Balance Training Compared to Conventional Physiotherapy on Balance and Quality of Life in Chemotherapy-Induced Peripheral Neuropathy: A Randomised Controlled Trial.
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Abstract
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect that leads to sensory deficits, impaired balance, and a reduced quality of life (QoL). This study evaluates the effectiveness of sensorimotor and balance training compared with conventional physiotherapy.
Objective: Determine whether integrating sensorimotor and balance training results in greater improvements in balance, neuropathic symptoms, and QoL among patients with CIPN.
Methods: A single-blinded randomised controlled trial was conducted with 86 participants undergoing neurotoxic chemotherapy. Outcomes, measured at baseline, Week 4, and follow-up at Week 6, included the Michigan Neuropathy Screening Instrument (MNSI), Berg Balance Scale (BBS), and Functional Assessment of Cancer Therapy-General (FACT-G).
Results: Linear mixed-effects modelling revealed significant group × time interactions for balance, physical well-being, emotional well-being, and functional well-being, favouring the experimental group (all p < 0.001). Large effect sizes were observed for balance (d = 0.70-0.82), physical well-being (d = 0.76-0.80), and functional well-being (d = 0.56-0.75). Social well-being showed a small, transient improvement at Week 4 (d = 0.32) that was not sustained at Week 6.
Conclusions: Sensorimotor and balance training significantly enhance balance, reduce neuropathic symptoms, and improve QoL in patients with CIPN.
期刊介绍：
Physiotherapy Research International is an international peer reviewed journal dedicated to the exchange of knowledge that is directly relevant to specialist areas of physiotherapy theory, practice, and research. Our aim is to promote a high level of scholarship and build on the current evidence base to inform the advancement of the physiotherapy profession. We publish original research on a wide range of topics e.g. Primary research testing new physiotherapy treatments; methodological research; measurement and outcome research and qualitative research of interest to researchers, clinicians and educators. Further, we aim to publish high quality papers that represent the range of cultures and settings where physiotherapy services are delivered. We attract a wide readership from physiotherapists and others working in diverse clinical and academic settings. We aim to promote an international debate amongst the profession about current best evidence based practice. Papers are directed primarily towards the physiotherapy profession, but can be relevant to a wide range of professional groups. The growth of interdisciplinary research is also key to our aims and scope, and we encourage relevant submissions from other professional groups. The journal actively encourages submissions which utilise a breadth of different methodologies and research designs to facilitate addressing key questions related to the physiotherapy practice. PRI seeks to encourage good quality topical debates on a range of relevant issues and promote critical reflection on decision making and implementation of physiotherapy interventions.
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