Carbonic anhydrase III.

Abstract

Carbonic anhydrase III (CA III) is a low-activity cytosolic isozyme that is highly expressed in skeletal muscle, liver, adipose tissue, and other tissues where it contributes to redox homeostasis, metabolism, and cell survival. CA III is now recognized as a multifunctional protein involved in antioxidant defense, lipid metabolism, adipogenesis, tissue repair, and disease processes including cancer. This chapter reviews the discovery, structure, catalytic features, physiological roles, and disease associations of CA III.