Hormone replacement therapy and complications after primary total shoulder arthroplasty.

IF 1.2 Q3 ORTHOPEDICS

Shoulder and Elbow Pub Date : 2026-07-21 DOI:10.1177/17585732261468740

Hailey Ninness, Chandler Catanzaro, Matthew Guareschi, Brandon L Rogalski, Josef K Eichinger, Richard J Friedman

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引用次数: 0

Abstract

Background: Hormone replacement therapy (HRT) is commonly prescribed to alleviate symptoms of menopause. Incidence of women undergoing total shoulder arthroplasty (TSA) continues to rise, yet the impact of HRT on primary TSA outcomes remains unclear. The purpose of this study is to examine the effects of HRT on postoperative complications following primary TSA.

Methods: The PearlDiver Mariner database was queried for menopausal aged females undergoing primary TSA between 2010 and 2023. Patients with prior history of breast cancer, deep vein thrombosis (DVT), pulmonary embolism, or stroke were excluded. Patients prescribed HRT within 365 days preoperatively were propensity score matched 1:1 to non-users. Chi-square analysis and multivariable logistic regression were used to evaluate associations between HRT use and postoperative complications. Statistical significance was defined as p < .05.

Results: HRT users had lower incidence of acute kidney injury (AKI) (p = .02) at 180 days and lower incidence of AKI (p = .03) and pneumonia (p = .04) at 365 days. HRT was found to be independently predictive of decreased rates of AKI (p = .03), UTI (p = .02), pneumonia (p = .01), and transfusion (p = .01) following TSA.

Conclusion: HRT was found to be independently associated with reduced medical complications following primary TSA and was not associated with surgical complications following primary TSA.

Level of evidence: Level III - Retrospective cohort study.

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原发性全肩关节置换术后激素替代治疗及并发症。

背景：激素替代疗法（HRT）通常用于缓解更年期症状。接受全肩关节置换术（TSA）的女性发病率持续上升，但HRT对TSA主要结果的影响尚不清楚。本研究的目的是探讨HRT对原发性TSA术后并发症的影响。方法：查询PearlDiver Mariner数据库中2010 - 2023年间接受原发性TSA的绝经期老年女性。既往有乳腺癌、深静脉血栓（DVT）、肺栓塞或中风病史的患者被排除在外。术前365天内接受HRT治疗的患者倾向评分与未接受HRT治疗的患者1:1匹配。采用卡方分析和多变量logistic回归评估HRT使用与术后并发症之间的关系。统计学意义定义为p 0.05。结果：HRT使用者在180天急性肾损伤（AKI）发生率较低（p = 0.02），在365天急性肾损伤（AKI）发生率较低（p = 0.03），肺炎发生率较低（p = 0.04）。HRT可独立预测AKI发生率的降低(p =。3), UTI (p =。02)，肺炎(p =。TSA后输血（p = 0.01）。结论：HRT被发现与原发性TSA后医疗并发症的减少独立相关，而与原发性TSA后手术并发症无关。证据等级：III级——回顾性队列研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Shoulder and Elbow Medicine-Rehabilitation

CiteScore

2.80

自引率

0.00%

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