Liver transplant program outcomes at a Colombian center: 14 years of experience.

Cirugia y cirujanos Pub Date : 2026-01-01 DOI:10.24875/CIRU.25000191

Maricel Licht-Ardila, Giseth A Mosquera-Velasquez, Angie V Abril-Lopera, Alexandra Hurtado-Ortiz, Luis A Olarte-Licht, Santiago Flórez-Suárez, Lizeth C Padilla-Padilla, Elizabeth C David-Gonzalez, Joel Duarte-Yepes, Alejandra Mendoza-Monsalve, Skarlet M Vásquez, Gabriel J Arenas-Peña, Mauricio Vanegas-Ballesteros, Cristian E Tarazona-Leon

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Abstract

Objectives: The objective of the study was to analyze outcomes of a liver transplant program over 14 years and evaluate associations between patient characteristics, surgical factors, complications, and mortality.

Methods: A retrospective cohort study was conducted at a transplant center, including patients from 2011 to 2025. Descriptive statistics, X², Mann-Whitney U tests, and multivariate logistic regression were used to identify mortality predictors. Kaplan-Meier survival analysis was also performed.

Results: The study included 109 liver transplant recipients. Rejection rates were higher among deceased patients (30.3% vs. 13.2%, p = 0.034). One-year survival improved from 63.3% (2011-2014) to 89.1% (2023-2025), with 100% rejection-free survival in the most recent cohort. Complications like multi-organ failure, bronchopneumonia, acute renal failure, ventilatory failure with coma, and leukoencephalopathy significantly increased mortality risk (odds ratio 4.27, p = 0.002).

Conclusions: One-year survival has improved, with reduced rejection rates reflecting better post-transplant care. However, complications remain a major mortality risk. Shorter ischemia times indicate optimized surgical and logistical procedures.

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哥伦比亚中心肝移植项目的结果：14年的经验。

目的：本研究的目的是分析14年来肝移植项目的结果，并评估患者特征、手术因素、并发症和死亡率之间的关系。方法：在某移植中心进行回顾性队列研究，纳入2011年至2025年的患者。采用描述性统计、X2、Mann-Whitney U检验和多变量logistic回归来确定死亡率预测因子。Kaplan-Meier生存分析。结果：纳入109例肝移植受者。死亡患者的排异率更高（30.3%比13.2%,p = 0.034）。一年生存率从63.3%（2011-2014年）提高到89.1%（2023-2025年），在最近的队列中达到100%的无排斥生存率。多器官功能衰竭、支气管肺炎、急性肾功能衰竭、呼吸衰竭伴昏迷和脑白质病等并发症显著增加了死亡风险（优势比4.27,p = 0.002）。结论：一年生存率提高，排异率降低反映了更好的移植后护理。然而，并发症仍然是一个主要的死亡风险。较短的缺血时间表明优化的手术和后勤程序。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cirugia y cirujanos

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