Urinary-tract infection by Mycoplasma pulmonis in mice and its wider implications.

D Taylor-Robinson, P M Furr
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引用次数: 4

Abstract

Young adult mice were inoculated intravenously with strains JB or Peter C of Mycoplasma pulmonis. A few were inoculated intranasally with strain JB. This strain but not Peter C was isolated for 50 days or more from the urines of more than half of the mice. Those of strains TO, C3H and CBA, but not CFLP, were susceptible. Recovery of mycoplasmas was intermittent and sometimes the numbers isolated varied within individual mice and between mice of a particular strain, ranging from 5 X 10(1) to greater than or equal to 5 X 10(7) colour-changing units/ml. Fifty serial passes of M. pulmonis, strain JB, in mycoplasmal medium resulted in attenuation, the organisms after inoculation of TO mice not being recovered from the urine and excretion not being stimulated by treating the mice with progesterone. At autopsy, the organisms of early passage were usually but not invariably isolated from the kidneys of mice that had been urinary excretors. About half of the latter had no renal histopathological changes. The others had usually minimal renal perivascular lymphocytic infiltrates but occasionally more widespread inflammatory changes. The findings may have relevance to the spread of mycoplasmal infection within mouse colonies and suggest that an association between such infection and nephritis in other species, including man, should be sought more closely.

小鼠肺支原体尿路感染及其广泛意义。
分别静脉注射肺支原体菌株JB和Peter C。少数用JB菌株鼻内接种。从一半以上的小鼠的尿液中分离出这一菌株(而不是Peter C) 50天或更长时间。菌株TO、C3H和CBA对CFLP不敏感。支原体的恢复是间歇性的,有时分离的数量在单个小鼠内和特定菌株的小鼠之间变化,范围从5 × 10(1)到大于或等于5 × 10(7)个变色单位/ml。在支原体培养基中连续传递50次肺支原体菌(JB株),结果是肺支原体菌在接种TO小鼠后不能从尿液中恢复,黄体酮也不能刺激小鼠的排泄。在尸体解剖中,早期传代的生物体通常(但并非总是)从曾经排泄尿液的老鼠的肾脏中分离出来。后者约半数未见肾组织病理改变。其他患者通常有轻微的肾血管周围淋巴细胞浸润,但偶尔有更广泛的炎症改变。这些发现可能与支原体感染在小鼠菌落内的传播有关,并表明这种感染与其他物种(包括人类)肾炎之间的联系应该得到更密切的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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