Bounded multiplicative dynamics govern axonal conduction slowdown.

IF 2.6 Q3 BIOPHYSICS
Biophysical reports Pub Date : 2026-09-09 Epub Date: 2026-07-17 DOI:10.1016/j.bpr.2026.100277
Shimon Marom
{"title":"Bounded multiplicative dynamics govern axonal conduction slowdown.","authors":"Shimon Marom","doi":"10.1016/j.bpr.2026.100277","DOIUrl":null,"url":null,"abstract":"<p><p>Conduction velocity slows along axons, yet the right-skewed distribution of the terminal-to-initial velocity ratio ρ = v<sub>end</sub>/v<sub>start</sub> has length-invariant mean and variance. A bounded multiplicative framework is introduced in which local geometric and kinetic factors compound proportionally but only within a finite distal domain set by termination conditions that saturate the effective multiplicative depth. The model accounts for the observed stability of the slowdown distribution across lengths and yields discriminating experimental signatures. More generally, it suggests that robust function can emerge through constrained variability rather than structural uniformity.</p>","PeriodicalId":72402,"journal":{"name":"Biophysical reports","volume":" ","pages":"100277"},"PeriodicalIF":2.6000,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452967/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysical reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.bpr.2026.100277","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/7/17 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0

Abstract

Conduction velocity slows along axons, yet the right-skewed distribution of the terminal-to-initial velocity ratio ρ = vend/vstart has length-invariant mean and variance. A bounded multiplicative framework is introduced in which local geometric and kinetic factors compound proportionally but only within a finite distal domain set by termination conditions that saturate the effective multiplicative depth. The model accounts for the observed stability of the slowdown distribution across lengths and yields discriminating experimental signatures. More generally, it suggests that robust function can emerge through constrained variability rather than structural uniformity.

有界乘法动力学控制轴突传导减速。
传导速度沿轴突方向变慢,但末初速度比ρ=vend/vstart的右偏分布具有长度不变的均值和方差。引入了一个有界乘法框架,其中局部几何因子和动力学因子按比例复合,但仅在由饱和有效乘法深度的终止条件设置的有限远端域内。该模型解释了观察到的长度上的减速分布的稳定性,并产生了鉴别的实验特征。更一般地说,它表明鲁棒功能可以通过约束变异性而不是结构一致性出现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Biophysical reports
Biophysical reports Biophysics
CiteScore
2.40
自引率
0.00%
发文量
0
审稿时长
75 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书