Short-Term Intraocular Pressure Changes After Intravitreal Aflibercept 8 mg via Prefilled Syringe.

IF 4.2 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2026-09-01 Epub Date: 2026-07-17 DOI:10.1007/s40123-026-01460-8

Arianna Peyla, Matteo Bonanata, Martina Pache, Michele Clerici, Moreno Menghini, Gabriela Grimaldi, Giulio Volpe

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引用次数: 0

Abstract

Introduction: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is a standard treatment for neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO). A transient rise in intraocular pressure (IOP) following injection is a well-established short-term effect. Aflibercept 8 mg has recently been introduced in a prefilled syringe (PFS), although data on its short-term effect on IOP are still lacking. The aim of this study was to assess short-term IOP changes after intravitreal aflibercept 8 mg administered via PFS and to compare these results with historical cohorts receiving aflibercept 8 mg via standard syringe and aflibercept 2 mg via PFS.

Methods: This single-centre comparative observational cohort study included a prospectively enrolled cohort of patients with nAMD or DMO receiving aflibercept 8 mg via PFS (0.07 mL), while two retrospective historical cohorts receiving aflibercept 8 mg via standard syringe (0.07 mL) or aflibercept 2 mg via PFS (0.05 mL) were used for comparison. IOP was measured with the iCare IC200 rebound tonometer at baseline (T0), 30 s (T1), 5 min (T2), and 15 min (T3) post-injection. Patients with glaucoma or ocular hypertension were excluded. Statistical analysis was performed using Friedman and Kruskal-Wallis tests.

Results: Forty-six eyes treated with aflibercept 8 mg PFS were analysed. Baseline IOP was similar across the three groups (p = 0.54). In the aflibercept 8 mg PFS cohort, mean IOP increased from 13.92 ± 4.25 mmHg at baseline to 51.29 ± 15.07 mmHg at 30 s, then fell to 31.32 ± 12.24 mmHg at 5 min and to 20.25 ± 7.08 mmHg at 15 min (p < 0.001). No statistically significant between-group differences were detected at any timepoint (all p ≥ 0.18).

Conclusion: Intravitreal aflibercept 8 mg administered via PFS was associated with a transient rise in IOP immediately after injection, which resolved within 15 min and was similar to that observed with aflibercept 2 mg via PFS and aflibercept 8 mg via standard syringe. These findings contribute to the characterization of the short-term IOP response associated with aflibercept 8 mg PFS administration and may help inform routine clinical practice.

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预充注射器注射阿非利塞8mg玻璃体后短期眼压变化。

玻璃体内抗血管内皮生长因子（anti-VEGF）治疗是新生血管性年龄相关性黄斑变性（nAMD）和糖尿病性黄斑水肿（DMO）的标准治疗方法。注射后眼压（IOP）一过性升高是一个公认的短期效应。afliberept 8mg最近被引入预充注射器（PFS），尽管其对IOP的短期影响数据仍然缺乏。本研究的目的是评估经PFS给药后，玻璃体内注射阿伯西普8mg后的短期IOP变化，并将这些结果与通过标准注射器接受阿伯西普8mg和通过PFS接受阿伯西普2mg的历史队列进行比较。方法：该单中心比较观察队列研究纳入了一组前瞻性纳入的nAMD或DMO患者，通过PFS接受阿非利西普8mg (0.07 mL)，而两个回顾性历史队列通过标准注射器接受阿非利西普8mg （0.07 mL）或通过PFS接受阿非利西普2mg （0.05 mL）进行比较。在注射后基线（T0）、30 s （T1）、5 min （T2）和15 min （T3）使用iCare IC200回弹眼压仪测量IOP。排除青光眼或高眼压患者。采用Friedman和Kruskal-Wallis检验进行统计分析。结果：对阿伯西普8mg PFS治疗的46只眼进行了分析。三组患者的基线IOP相似（p = 0.54）。aflibercept 8毫克PFS队列,意思是眼内压增加从13.92±4.25毫米汞柱从基线值的51.29±15.07毫米汞柱在30年代,然后跌至31.32±12.24毫米汞柱在5分钟和20.25±7.08毫米汞柱在15分钟(p结论:Intravitreal aflibercept 8毫克管理通过PFS与瞬态眼压上升后立即注射,15分钟内解决,类似于观察aflibercept 2毫克通过PFS和通过标准注射器aflibercept 8毫克。这些发现有助于表征与阿伯西普8mg PFS给药相关的短期IOP反应，并可能有助于常规临床实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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