Ju-Young Park, Su-Hyeon Park, Jung-Ho Lee, Young-Chun Park
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引用次数: 0
Abstract
Human feces are metabolic waste products that emit a wide range of volatile organic compounds, the result of dynamic interactions between gut microbiota and the host physiology. Fecal gas profiles are recognized as potential indicators of an individual's health status; however, most analyses rely on expensive laboratory equipment such as gas chromatography. In contrast, studies utilizing low-cost gas sensors for stool gas analysis remain limited, partly due to the high sensitivity of gas concentration data to environmental variables such as stool weight and ambient conditions. In this study, gas concentration data (ppm) were converted into normalized gas reduction ratio curves (%), referred to here as time curves, so that temporal gas-release patterns could be compared across samples with reduced influence from absolute signal differences. Fifteen stool samples were collected from four individuals and analyzed according to the Bristol stool scale. Time curves corresponding to the same Bristol stool type showed reproducible convergence into representative temporal profiles, where different stool types exhibited distinguishable gas-decay patterns. These findings suggest that time curve analysis may be useful for characterizing stool-type-related temporal gas patterns while reducing the influence of environmental variability in low-cost fecal gas sensing.
期刊介绍:
Journal of Breath Research is dedicated to all aspects of scientific breath research. The traditional focus is on analysis of volatile compounds and aerosols in exhaled breath for the investigation of exogenous exposures, metabolism, toxicology, health status and the diagnosis of disease and breath odours. The journal also welcomes other breath-related topics.
Typical areas of interest include:
Big laboratory instrumentation: describing new state-of-the-art analytical instrumentation capable of performing high-resolution discovery and targeted breath research; exploiting complex technologies drawn from other areas of biochemistry and genetics for breath research.
Engineering solutions: developing new breath sampling technologies for condensate and aerosols, for chemical and optical sensors, for extraction and sample preparation methods, for automation and standardization, and for multiplex analyses to preserve the breath matrix and facilitating analytical throughput. Measure exhaled constituents (e.g. CO2, acetone, isoprene) as markers of human presence or mitigate such contaminants in enclosed environments.
Human and animal in vivo studies: decoding the ''breath exposome'', implementing exposure and intervention studies, performing cross-sectional and case-control research, assaying immune and inflammatory response, and testing mammalian host response to infections and exogenous exposures to develop information directly applicable to systems biology. Studying inhalation toxicology; inhaled breath as a source of internal dose; resultant blood, breath and urinary biomarkers linked to inhalation pathway.
Cellular and molecular level in vitro studies.
Clinical, pharmacological and forensic applications.
Mathematical, statistical and graphical data interpretation.