Rubaina Dang, Raja K Sivamani, Adina Hazan, Isabelle Raymond
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引用次数: 0
Abstract
Introduction: Hair thinning is a multifactorial issue affecting women across life stages, frequently associated with reduced linear hair growth rate (LHGR). Hair growth nutraceuticals (HGNs) formulated with variations of a botanical-based multi-targeting complex are designed to address key root causes of hair thinning specific to different life stages. While prior studies have shown improvements in hair growth, quality, and fiber thickness, quantitative changes in LHGR have not been previously evaluated.
Methods: This prospective, 6-month study enrolled 180 women aged 18-70 years, assigned to one of four HGNs tailored for women at different life stages and diets. All subjects had self-reported hair thinning, confirmed by the study dermatologist. Participants were assessed at days 0, 90, and 180. Each timepoint included standardized hair clipping followed by objective analysis using Canfield HairMetrix® 48 h later, which included LHGR, hair counts, and anagen/telogen phase assessment. Self-assessment questionnaires were also completed at each post-baseline timepoint.
Results: A total of 150 participants completed the study per protocol. Daily ingestion of the tailored HGNs resulted in statistically significant increases in LHGR at both day 90 and day 180 compared with baseline across all four groups. Anagen hair counts rose significantly across the study duration in all groups, alongside gains in total and terminal hair counts. Total scalp coverage also significantly increased compared with baseline. The changes in hair parameters were corroborated with high agreement regarding improvements in hair parameters in the subject questionnaire.
Conclusions: This study demonstrates that consumption of these HGNs is associated with significant improvements in LHGR and other objective hair parameters in women experiencing hair thinning. These findings support the use of targeted HGNs as an effective strategy to enhance hair growth rate and overall hair health across different life stages.
期刊介绍：
Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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