Decoding MASLD progression beyond histological stages

IF 27.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2026-07-14 DOI:10.1038/s42255-026-01548-2

引用次数: 0

Abstract

We reconstruct metabolic dysfunction-associated steatotic liver disease (MASLD) as a continuous molecular trajectory, revealing dynamic regulatory programmes underlying disease progression. By integrating transcriptomics, network analysis and plasma proteomics, we identify a mechanistically grounded biomarker panel that enables non-invasive, stage-aware patient stratification beyond conventional histological staging.

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解码超越组织学阶段的MASLD进展

我们将代谢功能障碍相关的脂肪变性肝病（MASLD）重建为一个连续的分子轨迹，揭示了疾病进展背后的动态调控程序。通过整合转录组学、网络分析和血浆蛋白质组学，我们确定了一个机制基础的生物标志物面板，该面板可以实现非侵入性的、阶段感知的患者分层，超越传统的组织学分期。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.