Transcriptional signatures of cortical morphometric variability in temporal lobe epilepsy

IF 3.4 3区医学 Q2 CLINICAL NEUROLOGY

Epilepsia Open Pub Date : 2026-10-19 Epub Date: 2026-07-09 DOI:10.1002/epi4.70306

Yaping Dong, Shuai Wang, Jingjie Luo, Juan Meng, Yuanmei Liu, Song Zhang

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Abstract

Objective

Widespread cognitive deficits in temporal lobe epilepsy (TLE) are associated with macroscale brain structural changes. However, the correlation between the changes in the cortical morphological similarity of the TLE and gene expression remains unclear.

Methods

Structural magnetic resonance imaging (MRI) was collected from 31 TLE patients and 35 healthy controls to construct an individual-level Morphometric INverse Divergence (MIND) network. Changes in cortical morphological similarity attributable to TLE and their cognitive correlates were assessed. Using a public transcriptional dataset, we linked TLE-related structural changes to specific gene expression and biological pathways.

Results

TLE patients exhibited macroscopic morphological changes in the posterior cingulate cortex and dorsolateral prefrontal cortex, which were associated with cognitive impairments such as processing speed and working memory. Notably, TLE-related MIND changes were spatially correlated with the expression of epilepsy-associated genes, which were predominantly enriched in biological processes including cellular regulation and synaptic transmission.

Significance

MIND reveals macroscopic morphometric abnormalities of TLE. The microscopic transcriptional patterns have facilitated the understanding of the molecular mechanisms underlying cortical susceptibility.

Plain Language Summary

TLE patients often have memory and thinking problems. This study used brain scans to show that TLE patients have structural changes in two brain regions, the posterior cingulate cortex and dorsolateral prefrontal cortex. These changes are linked to slower processing speed and poorer working memory. Importantly, the brain changes were spatially related to the activity of TLE susceptibility genes involved in cell regulation and signal transmission between neurons. This helps explain how microscopic gene patterns may contribute to large-scale brain changes and cognitive difficulties in TLE.

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颞叶癫痫皮质形态变异的转录特征。

目的：颞叶癫痫（TLE）中广泛存在的认知缺陷与宏观脑结构改变有关。然而，颞叶皮层形态相似性的变化与基因表达之间的关系尚不清楚。方法：收集31例TLE患者和35例健康对照者的结构磁共振成像（MRI）数据，构建个体水平的形态反发散（MIND）网络。我们评估了TLE引起的皮质形态相似性的变化及其认知相关性。利用公共转录数据集，我们将与tle相关的结构变化与特定的基因表达和生物学途径联系起来。结果：TLE患者的后扣带皮层和背外侧前额叶皮层出现宏观形态学改变，与加工速度、工作记忆等认知障碍有关。值得注意的是，tle相关的MIND变化与癫痫相关基因的表达在空间上存在相关性，这些基因主要富集于细胞调节和突触传递等生物过程中。意义：MIND显示TLE的宏观形态学异常。微观转录模式有助于理解皮层易感性的分子机制。简单的语言总结：TLE患者经常有记忆和思维问题。这项研究使用脑部扫描显示，TLE患者在两个大脑区域，后扣带皮层和背外侧前额叶皮层有结构变化。这些变化与较慢的处理速度和较差的工作记忆有关。重要的是，大脑的变化在空间上与参与细胞调节和神经元间信号传递的TLE易感基因的活性有关。这有助于解释微观基因模式如何有助于TLE的大规模大脑变化和认知困难。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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