Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing-Remitting Multiple Sclerosis.

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2026-10-01 Epub Date: 2026-07-08 DOI:10.1002/acn3.70448

Stefano Ziccardi, Damiano Marastoni, Agnese Tamanti, Pietro Biasi, Valentina Visani, Annalisa Colombi, Tom A Fuchs, Monica Sicchieri, Chiara Eccher, Francesco Guarnaccia, Milena Calderone, Valentina Camera, Francesca Benedetta Pizzini, Roberta Magliozzi, Marco Castellaro, Massimiliano Calabrese

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引用次数: 0

Abstract

Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty-seven early relapsing-remitting MS patients were enrolled at diagnosis and followed longitudinally. PRLs and CP volume were evaluated at diagnosis using 3 T-MRI. Cognitive decline over time was classified as cognitive progression independent of relapse/MRI activity (PIRMA). Fifty-five patients (63.2%) showed meaningful cognitive decline: 44 (80.0%) were cognitive PIRMA. PRLs and CP volume at diagnosis were associated with cognitive PIRMA. PRLs and larger CP reflect cognitive progression independent of clinical/MRI activity, supporting their role as smoldering disease activity markers.

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在早期复发-缓解型多发性硬化症中，诊断时的顺磁边缘病变和脉络丛体积与认知进展相关，与复发和MRI活动无关。

顺磁边缘病变（prl）和脉络膜丛（CP）扩大反映多发性硬化症的阴燃炎症。它们在认知发展中的作用仍未被探索。87例早期复发缓解型MS患者在诊断时入组并进行纵向随访。诊断时使用3 T-MRI评估prl和CP体积。随着时间的推移，认知能力下降被归类为独立于复发/MRI活动（PIRMA）的认知进展。55例（63.2%）出现明显的认知能力下降，44例（80.0%）出现认知性PIRMA。诊断时prl和CP体积与认知性PIRMA相关。prl和较大CP反映了独立于临床/MRI活动的认知进展，支持它们作为阴燃疾病活动标志物的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.