CSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder

IF 7.6 1区医学 Q1 NEUROSCIENCES

Neuropsychopharmacology Pub Date : 2026-07-07 DOI:10.1038/s41386-026-02490-3

Wojciech Paslawski, Daniel Doyon, Carl Johan Ekman, Hampus Yngwe, Dejan Mamula, Justyna Zareba-Paslawska, Maria Beckman, Zhi-Qing David Xu, Tomas Hökfelt, Mikael Tiger, Johan Lundberg, Per Svenningsson

引用次数: 0

Abstract

Psilocybin is a rapid-acting antidepressant, but its mechanism of action in major depressive disorder remains unclear. In this secondary analysis of randomized, placebo-controlled trial with multimodal CSF and blood biomarker measurements, psilocybin selectively reduced CSF galanin and noradrenaline, implicating that normalization of these co-transmitters is a key pharmacodynamic signature.

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裸盖菇素治疗对重度抑郁症患者脑脊液甘丙氨酸和去甲肾上腺素下调的影响。

裸盖菇素是一种速效抗抑郁药，但其在重度抑郁症中的作用机制尚不清楚。在这项随机、安慰剂对照试验的多模式脑脊液和血液生物标志物测量的二次分析中，裸盖菇素选择性地降低了脑脊液丙氨酸和去甲肾上腺素，这意味着这些共递质的正常化是一个关键的药效学特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychopharmacology 医学-精神病学

CiteScore

15.00

自引率

2.60%

发文量

240

审稿时长

2 months

期刊介绍： Neuropsychopharmacology is a reputable international scientific journal that serves as the official publication of the American College of Neuropsychopharmacology (ACNP). The journal's primary focus is on research that enhances our knowledge of the brain and behavior, with a particular emphasis on the molecular, cellular, physiological, and psychological aspects of substances that affect the central nervous system (CNS). It also aims to identify new molecular targets for the development of future drugs. The journal prioritizes original research reports, but it also welcomes mini-reviews and perspectives, which are often solicited by the editorial office. These types of articles provide valuable insights and syntheses of current research trends and future directions in the field of neuroscience and pharmacology.