Next-generation methods in health technology assessment (HTA): need, rigor, and implementability.

Abstract

The Health Technology Assessment International (HTAi) 2025 annual meeting featured three main plenaries to explore next-generation (NextGen) evidence in health technology assessment (HTA). In this commentary, we capture the discussions of Plenary 2: NextGen Methods: Hype or Here to Stay? Each plenary panelist was tasked to convincingly debate the need, rigor, and implementability of one of three emerging method domains in HTA: (1) Environmental Sustainability, (2) Adaptive HTA, and (3) Artificial Intelligence (AI)-enabled Real-World Evidence (RWE). The three panelists convincingly debated that their method would endure beyond initial hype; all three methods were perceived to have a moderate to high level of need, rigor, and implementability by the audience. Key questions from the audience included a request for examples of where HTA reviews have considered environmental sustainability, a challenge for adaptive HTA to embrace other value elements outside of cost-effectiveness, and a question about how the human-in-the-loop principle fits into AI-driven RWE and what this means for HTA agencies that are already stretched for resources. In this commentary, we summarize the presentations, discussions, and audience engagement to provide readers with accessible insight into the debate about which method(s) are anticipated to endure beyond their initial hype.