{"title":"Artificial Intelligence-Powered Algal Biodiesel: The Future of Biofuel Production Through Data-Driven Biotechnology","authors":"Gyanendra Tripathi","doi":"10.1002/bit.70305","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Microalgae are promising feedstocks for sustainable biodiesel production, although their industrial use is currently limited by their biological complexity and high production costs. Recently, artificial intelligence (AI) technologies have been identified as promising, game-changing tools that could optimize algal biodiesel processes by leveraging data-driven biology. The purpose of this Review is to provide an integrated summary of recent developments in machine learning, deep learning, and hybrid models of microalgal biodiesel, analyzing AI frameworks that integrate biological and physical information with microalgal biodiesel process models to improve productivity, biological stability, and sustainability. It is essential to critically analyze the challenges of data quality and explainability in machine learning models, and to explain their use in techno-economic analysis of microalgal biodiesel. In the final part, directions for developing an independent microalgal biorefinery system using artificial intelligence tools are outlined to accelerate the lab-to-production transition of climate-relevant biofuels.</p></div>","PeriodicalId":9168,"journal":{"name":"Biotechnology and Bioengineering","volume":"123 11","pages":"2968-2983"},"PeriodicalIF":3.9000,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biotechnology and Bioengineering","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bit.70305","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/7/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Microalgae are promising feedstocks for sustainable biodiesel production, although their industrial use is currently limited by their biological complexity and high production costs. Recently, artificial intelligence (AI) technologies have been identified as promising, game-changing tools that could optimize algal biodiesel processes by leveraging data-driven biology. The purpose of this Review is to provide an integrated summary of recent developments in machine learning, deep learning, and hybrid models of microalgal biodiesel, analyzing AI frameworks that integrate biological and physical information with microalgal biodiesel process models to improve productivity, biological stability, and sustainability. It is essential to critically analyze the challenges of data quality and explainability in machine learning models, and to explain their use in techno-economic analysis of microalgal biodiesel. In the final part, directions for developing an independent microalgal biorefinery system using artificial intelligence tools are outlined to accelerate the lab-to-production transition of climate-relevant biofuels.
期刊介绍:
Biotechnology & Bioengineering publishes Perspectives, Articles, Reviews, Mini-Reviews, and Communications to the Editor that embrace all aspects of biotechnology. These include:
-Enzyme systems and their applications, including enzyme reactors, purification, and applied aspects of protein engineering
-Animal-cell biotechnology, including media development
-Applied aspects of cellular physiology, metabolism, and energetics
-Biocatalysis and applied enzymology, including enzyme reactors, protein engineering, and nanobiotechnology
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-Biofuels, including biomass and renewable resource engineering
-Biomaterials, including delivery systems and materials for tissue engineering
-Bioprocess engineering, including kinetics and modeling of biological systems, transport phenomena in bioreactors, bioreactor design, monitoring, and control
-Biosensors and instrumentation
-Computational and systems biology, including bioinformatics and genomic/proteomic studies
-Environmental biotechnology, including biofilms, algal systems, and bioremediation
-Metabolic and cellular engineering
-Plant-cell biotechnology
-Spectroscopic and other analytical techniques for biotechnological applications
-Synthetic biology
-Tissue engineering, stem-cell bioengineering, regenerative medicine, gene therapy and delivery systems
The editors will consider papers for publication based on novelty, their immediate or future impact on biotechnological processes, and their contribution to the advancement of biochemical engineering science. Submission of papers dealing with routine aspects of bioprocessing, description of established equipment, and routine applications of established methodologies (e.g., control strategies, modeling, experimental methods) is discouraged. Theoretical papers will be judged based on the novelty of the approach and their potential impact, or on their novel capability to predict and elucidate experimental observations.