Synthesis and structure of norfloxacinium acetate sesquihydrate

IF 0.5 Q4 CRYSTALLOGRAPHY

Acta Crystallographica Section E: Crystallographic Communications Pub Date : 2026-07-01 Epub Date: 2026-07-13 DOI:10.1107/S2056989026005670

Abdusamat Rasulov, Batirbay Torambetov, Aziza Erejepova, Umidjon Annaev, Jabbor Suyunov, Bekmurod Alimnazarov, Jamshid Ashurov

引用次数: 0

Abstract

The title hydrated salt, C₁₆H₁₉FN₃O₃⁺·C₂H₃O₂⁻·1.5H₂O, crystallizes with two cations, two anions and three water molecules of crystallization in the asymmetric unit. The protonation of the piperazine secondary amine group of norfloxacin occurs via proton transfer from acetic acid. In the extended structure, the components are linked into chains propagating along the a-axis direction through numerous N—H⋯O and O—H⋯O hydrogen bonds. Hirshfeld surface analysis and two-dimensional fingerprint plots confirm the significant contribution of H⋯O interactions to the consolidation of the crystal structure.

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半水合醋酸去氟沙星的合成与结构。

标题水合盐C16H19FN3O3 +·C2H3O2 -·1.5H2O在不对称单元中以2个阳离子、2个阴离子和3个水分子结晶。诺氟沙星哌嗪仲胺基的质子化是通过醋酸的质子转移发生的。在扩展结构中，组分通过无数N-H⋯O和O- h⋯O氢键连接成沿a轴方向传播的链。Hirshfeld表面分析和二维指纹图证实了H⋯O相互作用对晶体结构固结的重要贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Crystallographica Section E: Crystallographic Communications Chemistry-Chemistry (all)

CiteScore

1.90

自引率

0.00%

发文量

351

审稿时长

3 weeks

期刊介绍： Acta Crystallographica Section E: Crystallographic Communications is the IUCr''s open-access structural communications journal. It provides a fast, simple and easily accessible publication mechanism for crystal structure determinations of inorganic, metal-organic and organic compounds. The electronic submission, validation, refereeing and publication facilities of the journal ensure rapid and high-quality publication of fully validated structures. The primary article category is Research Communications; these are peer-reviewed articles describing one or more structure determinations with appropriate discussion of the science.