Crystal structure of the meso compound (2R,6S)-4-(5-bromo­pyrimidin-2-yl)-2,6-di­methyl­morpholine

Abstract

The title compound, C₁₀H₁₄N₃OBr, was prepared by a nucleophilic aromatic substitution reaction between 2,6-di­methyl­morpholine and 2-chloro­pyrimidine, followed by bromination of the pyrimidine ring. The compound crystallizes in the monoclinic system (space group P2₁/c) with four mol­ecules in the unit cell (Z = 4). The mol­ecule exhibits approximate C_S point-group symmetry (r.m.s. deviation: 0.1072 Å). The arrangement of the mol­ecules in the solid state is dominated by close packing. C—H⋯N contacts between pyrimidinyl rings in adjacent mol­ecules with an R²₂(6) motif are encountered, whereas the bromine atom does not exhibit any short contacts that could be regarded as halogen bonds.