Cost-effectiveness of community versus hospital-based mental healthcare for severe mental illness in South-East Europe: economic evaluation of five randomised trials.

IF 3.1 3区 医学 Q1 ECONOMICS
Ben Wijnen, Filip Smit, Ana Ivičević Uhernik, Ana Žegrec, Jovo Dedovic, Roumyana Dinolova, Raluca Nica, Aleksander Tomcuk, Robert Velickovski, Michel Wensing, Laura Shields-Zeeman, Ionela Petrea
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引用次数: 0

Abstract

Introduction: The RECOVER-E project supported the shift away from mental health care provided in institutional settings (treatment as usual, TAU) towards community-based mental healthcare by introducing multidisciplinary community mental health teams (CMHT) for people with schizophrenia, bipolar disorder, and severe depression across five sites in Bulgaria, Croatia, Montenegro, North Macedonia, and Romania. This paper presents the cost-effectiveness of CMHT compared to TAU.

Methods: Data from all five RECOVER-E trials (N = 931) was used to compute healthcare costs and societal costs which included additional patient and family costs, and costs stemming from productivity losses. Outcomes were incremental cost-effectiveness ratio's (ICER) for gaining a QALY and gaining a treatment responder (based on WHODAS 2.0).

Results: Compared to TAU, CMHT had small incremental effects favouring CMHT (QALY: M = 0·023, SD = 0·013; Response: M = 0·093, SD = 0·034). The incremental costs were higher in CMHT than in TAU as seen from both the societal and healthcare perspective (societal costs: M=€1,892, SD=€950; healthcare costs: M = 1,125, SD=€720). The ICER for gaining a QALY was €82,261 and €48,913 as seen from the societal and healthcare perspective, respectively. These ICERs were well above the willingness to pay threshold of €20,000 for gaining a QALY. A similar picture arose with treatment response as outcome.

Conclusion: Overall CMHT appeared to be more effective but also more costly, with the additional cost outweighing the benefits across countries, except in Bulgaria, which may highlight that cost-effectiveness is likely to be context dependent. Therefore, a recommendation for scaling up or sustaining CMHT must also depend on arguments other than health-economic alone, such as medical ethical, equity and human rights considerations.

Trial registration: Bulgaria: NCT03922425, Croatia: NCT03862209, Macedonia: NCT03892473, Montenegro: NCT03837340, Romania NCT03884933.

东南欧严重精神疾病的社区与医院精神保健的成本效益:五项随机试验的经济评价
引言:RECOVER-E项目通过在保加利亚、克罗地亚、黑山、北马其顿和罗马尼亚的五个地点为精神分裂症、双相情感障碍和严重抑郁症患者引入多学科社区精神卫生小组(CMHT),支持从机构环境中提供的精神卫生保健(常规治疗,TAU)向社区精神卫生保健的转变。本文介绍了CMHT与TAU相比的成本效益。方法:使用来自所有五个recovery - e试验(N = 931)的数据来计算医疗保健成本和社会成本,其中包括额外的患者和家庭成本,以及因生产力损失而产生的成本。结果是获得QALY和获得治疗反应的增量成本-效果比(ICER)(基于WHODAS 2.0)。结果:与TAU相比,CMHT具有较小的增量效应(QALY: M = 0.023, SD = 0.013;响应:M = 0.093, SD = 0.034)。从社会和医疗保健的角度来看,CMHT的增量成本高于TAU(社会成本:M= 1,892欧元,SD= 950欧元;医疗保健成本:M= 1,125欧元,SD= 720欧元)。从社会和医疗保健的角度来看,获得QALY的成本分别为82,261欧元和48,913欧元。这些icer远高于愿意支付2万欧元获得QALY的门槛。治疗反应作为结果也出现了类似的情况。结论:总体而言,CMHT似乎更有效,但也更昂贵,除了保加利亚之外,其他国家的额外成本超过了收益,这可能突出了成本效益可能取决于具体情况。因此,关于扩大或维持CMHT的建议也必须依赖于卫生经济以外的论据,例如医学伦理、公平和人权考虑。试验注册:保加利亚:NCT03922425,克罗地亚:NCT03862209,马其顿:NCT03892473,黑山:NCT03837340,罗马尼亚:NCT03884933。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.10
自引率
2.30%
发文量
131
期刊介绍: The European Journal of Health Economics is a journal of Health Economics and associated disciplines. The growing demand for health economics and the introduction of new guidelines in various European countries were the motivation to generate a highly scientific and at the same time practice oriented journal considering the requirements of various health care systems in Europe. The international scientific board of opinion leaders guarantees high-quality, peer-reviewed publications as well as articles for pragmatic approaches in the field of health economics. We intend to cover all aspects of health economics: • Basics of health economic approaches and methods • Pharmacoeconomics • Health Care Systems • Pricing and Reimbursement Systems • Quality-of-Life-Studies The editors reserve the right to reject manuscripts that do not comply with the above-mentioned requirements. The author will be held responsible for false statements or for failure to fulfill the above-mentioned requirements. Officially cited as: Eur J Health Econ
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