Dirk Kleindienst, Justyna Mohr, Katharina Maurer, Eva Kalkum, Julian-Camill Harnoss, Pia Antony, Alexander Dullenkopf, Pietro Renzulli, Pascal Probst, Markus K Mueller
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引用次数: 0
Abstract
Purpose: Appendicitis is one of the most common diseases of the gastrointestinal tract with a lifetime incidence of 7 to 9%. Appendectomy is one of the most performed emergency surgeries. Recently, non-operative treatments are emerging. It is almost impossible to keep the overview on the large and growing body of evidence on appendicitis. Therefore, the aim of this project was to create a systematic and living Evidence Map of Appendicitis.
Methods: PubMed, CENTRAL, Web of Science, EMBASE were systematically and continuously searched for all published and ongoing randomized controlled trials (RCT) and systematic reviews (SR) dealing with diagnosis and treatment of appendicitis. Outcomes from every existing RCT were extracted and trial quality was assessed. RCTs and SRs on identical subjects were grouped to research topics. For specific treatment outcomes, meta-analyses were performed for all research topics with more than 3 RCTs.
Results: Out of 16373 articles screened, 527 RCTs on 104331 patients and 408 SRs were included and grouped into 74 research topics with 31 living meta-analyses. Most RCTs were from Asia (43%),followed by Europe (32%) and North America (15%). Living meta-analyses were performed for 31 out of 74 research topics. For three out of 74 research topics (4%) there were no RCT available.
Conclusion: The Evidence Map of Appendicitis is the ultimate go-to source for evidence on appendicitis. Constantly updated and freely accessible via www.EVIglance.com and as mobile phone app. Clinical decision-making, evidence-based patient information are supported by the primary data provided, as well as by living meta-analyses.
期刊介绍：
Langenbeck''s Archives of Surgery aims to publish the best results in the field of clinical surgery and basic surgical research. The main focus is on providing the highest level of clinical research and clinically relevant basic research. The journal, published exclusively in English, will provide an international discussion forum for the controlled results of clinical surgery. The majority of published contributions will be original articles reporting on clinical data from general and visceral surgery, while endocrine surgery will also be covered. Papers on basic surgical principles from the fields of traumatology, vascular and thoracic surgery are also welcome. Evidence-based medicine is an important criterion for the acceptance of papers.
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