Spatial transcriptomics in cancer research: insights into tumorigenesis, diagnosis and therapeutics.

IF 10.4 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2026-06-30 DOI:10.1038/s41420-026-03092-0

Qiang Wen, Qing Lan, Jianjian Yin, Fei Guo, Xiaosong Wei, Caiyun Wu, Lei Jin, Xu D Zhang, Jinyan Li, Lirong Zhang, Tao Liu

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Abstract

Spatial transcriptomics is an innovative technology that enables high-throughput, genome-wide analysis of transcript expression and spatial localization within tissues. By preserving structural organization, it provides critical insights into tumor sub-regions, substructures, and the heterogeneity and plasticity of cancer, stromal, and immune cells, as well as cell-cell interactions. Spatial transcriptomics also offers an unprecedented understanding of the tumor microenvironment, including immune cell infiltration, activation and repression, and immune suppression mediated by stromal cells. Importantly, it deepens our understanding of malignant transformation from precancerous lesions, tumorigenesis, and immune escape. Furthermore, spatial transcriptomics is reshaping cancer subtype diagnosis and risk stratification, uncovering factors associated with drug resistance, predicting therapy responses, and informing the development of personalized cancer treatments and potentially prevention. In summary, spatial transcriptomics serves as a cornerstone of cancer research, transforming the research landscape and unlocking groundbreaking opportunities for precision cancer diagnosis, risk stratification, targeted therapy, and prevention.

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肿瘤研究中的空间转录组学：对肿瘤发生、诊断和治疗的见解。

空间转录组学是一项创新技术，可以对组织内的转录表达和空间定位进行高通量、全基因组分析。通过保留结构组织，它提供了对肿瘤亚区、亚结构、癌症、基质和免疫细胞的异质性和可塑性以及细胞间相互作用的重要见解。空间转录组学还提供了对肿瘤微环境的前所未有的理解，包括免疫细胞的浸润、激活和抑制，以及基质细胞介导的免疫抑制。重要的是，它加深了我们对癌前病变、肿瘤发生和免疫逃逸的恶性转化的理解。此外，空间转录组学正在重塑癌症亚型诊断和风险分层，揭示与耐药相关的因素，预测治疗反应，并为个性化癌症治疗和潜在预防的发展提供信息。总之，空间转录组学是癌症研究的基石，改变了研究格局，为精确癌症诊断、风险分层、靶向治疗和预防提供了开创性的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.