Meeting report for the Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026)

IF 7.4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Translational Research and Clinical Interventions Pub Date : 2026-06-30 DOI:10.1002/trc2.70281

Jane Alshami, Ginny Wu, B. Maximiliano Garduño, Afonso C. Silva, Stacey J. Sukoff Rizzo, Patricia Cogram, Xiangmin Xu

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Abstract

The Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026) was held February 9 through 11, 2026, in Irvine, California. Building upon the inaugural meeting in Santiago, Chile (2023), this conference expanded an international effort to develop, characterize, and rigorously evaluate non-traditional animal models with enhanced translational relevance for Alzheimer's disease (AD) and aging research. The meeting convened leading investigators across genomics, systems neuroscience, comparative biology, and pathology to discuss naturally occurring and engineered models including degu (Octodon degus), dog (Canis lupus familiaris), marmoset (Callithrix jacchus), rhesus macaque (Macaca mulatta), naked mole-rat (Heterocephalus glaber), and emerging large animal species including elephants and whales. A central theme was the need for cross-species integration of multimodal and multi-scale approaches to interrogate cellular vulnerability, gene regulatory programs, and age-associated neuropathology and circuit alterations across species. UAMAA 2026 emphasized cross-species comparison, human brain atlas integration, and translational alignment with National Institutes of Health priorities. The conference highlighted growing momentum toward a diversified model ecosystem aimed at accelerating mechanistic insight and therapeutic discovery in AD and aging research. A special journal issue associated with the conference has been announced to extend these themes into peer-reviewed scientific discourse.

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第二届阿尔茨海默病与衰老的非常规动物模型国际会议（UAMAA 2026）会议报告

第二届阿尔茨海默病和衰老的非常规动物模型国际会议（UAMAA 2026）于2026年2月9日至11日在加州尔湾举行。在智利圣地亚哥（2023年）举行的首次会议的基础上，本次会议扩大了国际努力，以开发、表征和严格评估具有增强阿尔茨海默病（AD）和衰老研究转化相关性的非传统动物模型。会议召集了基因组学、系统神经科学、比较生物学和病理学领域的主要研究人员，讨论了自然发生的和工程模型，包括degu （Octodon degus）、狗（Canis lupus familiaris）、狨猴（Callithrix jacchus）、恒河猴（Macaca mulatta）、裸鼹鼠（Heterocephalus glaber）和新兴的大型动物物种，包括大象和鲸鱼。一个中心主题是需要跨物种整合多模式和多尺度的方法来询问细胞脆弱性、基因调控程序、年龄相关的神经病理学和跨物种的回路改变。UAMAA 2026强调跨物种比较、人类大脑图谱整合以及与美国国立卫生研究院优先事项的转化对齐。会议强调了多样化模型生态系统的发展势头，旨在加速阿尔茨海默病和衰老研究的机制洞察和治疗发现。与会议相关的一期特别期刊已宣布将这些主题扩展到同行评议的科学论述中。

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来源期刊

Alzheimer''s and Dementia: Translational Research and Clinical Interventions Medicine-Psychiatry and Mental Health

CiteScore

10.10

自引率

2.10%

发文量

134

审稿时长

10 weeks

期刊介绍： Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.