Aryl hydrocarbon receptor nuclear translocator 2: a forgotten per-ARNT-Sim transcription factor.

IF 5.2 3区医学 Q2 TOXICOLOGY

Toxicological Sciences Pub Date : 2026-07-01 DOI:10.1093/toxsci/kfag078

Israt Jahan, Yadeliz A Serrano Matos, Arul Jayaraman, Aditya D Joshi

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Abstract

Aryl hydrocarbon receptor nuclear translocator 2 is a member of the basic helix-loop-helix/Per-ARNT-Sim family of transcription factors involved in responding to various environmental, metabolic, and chemical signals. Initially known for its involvement in neurodevelopment, ARNT2 is now recognized as an essential binding partner for other transcription factors, including single-minded homologs 1 and 2, neuronal PAS domain protein 4, hypoxia-inducible factor 1, and plausibly Aryl hydrocarbon receptor to regulate stress adaptation, synaptic plasticity, immune signaling, and energy balance pathways. The role of ARNT2 has also been implicated in a plethora of pathologies, including inflammation, cardiovascular diseases, neurological disorders, metabolic diseases, and cancers. This review summarizes the current knowledge of ARNT2's structure, regulation, interacting partners, and its toxicopathological significance. A better understanding of ARNT2 biology may open new avenues for its characterization as a molecular target and designing novel therapeutic strategies across multiple diseases.

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芳烃受体核转运子2：一个被遗忘的Per-ARNT-Sim转录因子。

芳烃受体核转运子2是基本的helix-loop-helix/Per-ARNT-Sim （bHLH-PAS）转录因子家族的成员，参与响应各种环境，代谢和化学信号。最初以参与神经发育而闻名，现在被认为是其他转录因子的重要结合伙伴，包括单一同源物1和2 (SIM1, SIM2)，神经元PAS结构域蛋白4 (NPAS4)，缺氧诱导因子1 （HIF1）和芳烃受体（AHR），以调节应激适应，突触可塑性，免疫信号传导和能量平衡途径。ARNT2的作用也与多种病理有关，包括炎症、心血管疾病、神经系统疾病、代谢疾病和癌症。本文综述了目前关于ARNT2的结构、调控、相互作用伙伴及其毒理学意义的研究进展。更好地了解ARNT2生物学可能为其作为分子靶点的表征和设计跨多种疾病的新治疗策略开辟新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicological Sciences 医学-毒理学

CiteScore

7.70

自引率

7.90%

发文量

118

审稿时长

1.5 months

期刊介绍： The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish a broad spectrum of impactful research in the field of toxicology. The primary focus of Toxicological Sciences is on original research articles. The journal also provides expert insight via contemporary and systematic reviews, as well as forum articles and editorial content that addresses important topics in the field. The scope of Toxicological Sciences is focused on a broad spectrum of impactful toxicological research that will advance the multidisciplinary field of toxicology ranging from basic research to model development and application, and decision making. Submissions will include diverse technologies and approaches including, but not limited to: bioinformatics and computational biology, biochemistry, exposure science, histopathology, mass spectrometry, molecular biology, population-based sciences, tissue and cell-based systems, and whole-animal studies. Integrative approaches that combine realistic exposure scenarios with impactful analyses that move the field forward are encouraged.