Banhi Biswas, Junlin Zhuo, Jürgen Bosch, Hien Vu, Lorencia Pak, Rameez Raja, Anuradha Roy, Alessandro Panattoni, Michal Maryska, Petr Slavik, Kryštof Šigut, Anthony R Fehr, Rachy Abraham, Barbara S Slusher, Takashi Tsukamoto, Anthony K L Leung
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引用次数: 0
Abstract
Coronavirus macrodomains (Mac1) counter host immunity by removing ADP-ribose. GS-441524, the parent nucleoside of remdesivir, inhibits SARS-CoV-2 Mac1, but its active metabolite and cellular engagement were undefined. GS-441524 selectively inhibits SARS-CoV-2 Mac1 over human MacroD2, engages Mac1 in cells but not MERS-CoV Mac1, with its diphosphate metabolite being most potent.
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