Serum Sclerostin Correlates with ACPA Positivity in Post-Menopausal Women with Rheumatoid Arthritis: Data from a Cross-Sectional Case-Control Study in Greece.

IF 2.1 Q4 Medicine

Mediterranean Journal of Rheumatology Pub Date : 2026-03-27 eCollection Date: 2026-06-01 DOI:10.31138/mjr.190425.eda

Michail I Krikelis, Dimitra Moschou, Konstantina Zoupidou, Evangelia Mole, Konstantinos Makris, Simeon Tournis, Sousana Gazi, Vassilios Nikolaou, Clio Mavragani, Efstathios Chronopoulos

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Abstract

Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease marked by bone loss, partly due to impaired Wnt signalling. The role of sclerostin, an endogenous Wnt inhibitor, in RA remains unclear.

Methods: This 9-month cross-sectional case-control study included post-menopausal women recruited at a tertiary hospital in Athens, Greece. Participants underwent clinical assessment, DXA, radiographs, and blood tests. The aim was to assess serum sclerostin levels and their associations in RA.

Results: A total of 97 RA patients and 45 controls were included. Mean age was 67 ± 7 years; median RA duration was 8 years; 40% were seropositive; 65% received bDMARDs. Median sclerostin levels did not differ significantly between groups (p=0.645). In RA patients, sclerostin levels were positively associated with ACPA (p=0.043). Notably, 27% of RA patients had extremely high sclerostin levels versus 11% of controls (p=0.035). Within this subgroup, high sclerostin was inversely associated with sarcopenia (p=0.020).

Discussion: Although overall sclerostin levels were similar between groups, higher levels in seropositive RA suggest a possible link with ACPA.

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绝经后类风湿关节炎妇女血清硬化蛋白与ACPA阳性相关：来自希腊横断面病例对照研究的数据

类风湿性关节炎（RA）是一种以骨质流失为特征的慢性炎症性疾病，部分原因是Wnt信号受损。内源性Wnt抑制剂sclerostin在RA中的作用尚不清楚。方法：这项为期9个月的横断面病例对照研究纳入了在希腊雅典一家三级医院招募的绝经后妇女。参与者接受了临床评估、DXA、x光片和血液检查。目的是评估血清硬化蛋白水平及其与RA的关系。结果：共纳入97例RA患者和45例对照组。平均年龄67±7岁；中位RA持续时间为8年；血清阳性40%；65%的人接受了bdmard。组间中位硬化蛋白水平差异无统计学意义（p=0.645）。在RA患者中，硬化蛋白水平与ACPA呈正相关（p=0.043）。值得注意的是，27%的RA患者有极高的硬化蛋白水平，而对照组为11% （p=0.035）。在这个亚组中，高硬化蛋白与肌肉减少症呈负相关（p=0.020）。讨论：尽管两组之间的总硬化蛋白水平相似，血清阳性RA的较高水平提示可能与ACPA有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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