Electrochemical Sensor Based on Perovskite Hydroxide and Carbon Black Nanocomposite for the Selective Detection of Crizotinib

IF 3.2 4区化学 Q3 CHEMISTRY, PHYSICAL

Electrocatalysis Pub Date : 2026-06-10 DOI:10.1007/s12678-026-01043-y

Mahmoud Roushani, Zahra Mirzaei Karazan, Hasan Dakhil Medley

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Abstract

Crizotinib (CZT) is an anaplastic lymphoma kinase (ALK) inhibitor used for the treatment of lung cancer. The selective detection of CZT in human biological samples is crucial for therapeutic studies. Electrochemical sensors have become essential in pharmaceutical analysis due to their high selectivity, fast response, low costs, simplicity, and portability. Here, an effective and novel electrochemical sensor based on a perovskite hydroxide CoSn(OH)₆/carbon black (CB) nanocomposite was designed for the highly selective detection of CZT on a glassy carbon electrode (GCE) surface. Characterization techniques such as field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and electrochemical methods such as electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV) confirmed the structural and electrochemical properties of the nanocomposite. The sensor exhibited a wide linear range of 0.001 to 2400 nM, a limit of detection (LOD) of 0.0003 nM, and acceptable selectivity, reproducibility, repeatability, and stability for CZT detection. Finally, the designed electrode was used to determine CZT in a real sample, displaying its promise for pharmaceutical and biomedical applications.

Graphical Abstract

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基于氢氧化钙钛矿和炭黑纳米复合材料的电化学传感器选择性检测克唑替尼

克唑替尼（CZT）是一种间变性淋巴瘤激酶（ALK）抑制剂，用于治疗肺癌。人类生物样品中CZT的选择性检测对治疗研究至关重要。电化学传感器由于其高选择性、快速响应、低成本、简单和便携性，在药物分析中已成为必不可少的。本文设计了一种基于氢氧化钙钛矿CoSn(OH)6/炭黑（CB）纳米复合材料的高效新型电化学传感器，用于玻璃碳电极（GCE）表面CZT的高选择性检测。表征技术如场发射扫描电镜（FE-SEM）、x射线衍射（XRD）和电化学方法如电化学阻抗谱（EIS）、循环伏安法（CV）和差分脉冲伏安法（DPV）证实了纳米复合材料的结构和电化学性能。该传感器具有较宽的线性范围（0.001 ~ 2400 nM），检出限（LOD）为0.0003 nM，对CZT检测具有良好的选择性、再现性、重复性和稳定性。最后，将设计的电极用于实际样品中的CZT测定，显示了其在制药和生物医学领域的应用前景。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Electrocatalysis CHEMISTRY, PHYSICAL-ELECTROCHEMISTRY

CiteScore

4.80

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： Electrocatalysis is cross-disciplinary in nature, and attracts the interest of chemists, physicists, biochemists, surface and materials scientists, and engineers. Electrocatalysis provides the unique international forum solely dedicated to the exchange of novel ideas in electrocatalysis for academic, government, and industrial researchers. Quick publication of new results, concepts, and inventions made involving Electrocatalysis stimulates scientific discoveries and breakthroughs, promotes the scientific and engineering concepts that are critical to the development of novel electrochemical technologies. Electrocatalysis publishes original submissions in the form of letters, research papers, review articles, book reviews, and educational papers. Letters are preliminary reports that communicate new and important findings. Regular research papers are complete reports of new results, and their analysis and discussion. Review articles critically and constructively examine development in areas of electrocatalysis that are of broad interest and importance. Educational papers discuss important concepts whose understanding is vital to advances in theoretical and experimental aspects of electrochemical reactions.