Metabolic and Synthetic Biology Strategies for Enhancing Single-Cell Protein Production in Saccharomyces cerevisiae.

IF 3.7 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

Biotechnology Journal Pub Date : 2026-06-01 DOI:10.1002/biot.70273

Xiaoyu Wang, Huayou Chen, Huiqing Chen, Hongwei Yu, Lidan Ye, Zhongjian Guo

引用次数: 0

Abstract

Single cell protein (SCP), distinguished by its high production efficiency, flexible substrate utilization, and excellent nutritional value, has broad application prospects in both feed and food sectors. With the advancement of synthetic biology and metabolic engineering, SCP is poised to become a mainstream protein source, providing key solutions for global food security and carbon neutrality goals. This review focuses on Saccharomyces cerevisiae as an SCP chassis and summarizes recent metabolic and synthetic biology strategies aimed at enhancing cellular protein content and cell biomass, thereby improving its potential for sustainable large-scale protein production.

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提高酿酒酵母单细胞蛋白产量的代谢和合成生物学策略。

单细胞蛋白（Single cell protein， SCP）具有生产效率高、底物利用灵活、营养价值优异等特点，在饲料和食品领域都有广阔的应用前景。随着合成生物学和代谢工程的进步，SCP有望成为主流蛋白质来源，为全球粮食安全和碳中和目标提供关键解决方案。本文综述了酿酒酵母作为SCP的基础，并总结了最近的代谢和合成生物学策略，旨在提高细胞蛋白质含量和细胞生物量，从而提高其可持续大规模蛋白质生产的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology Journal Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

8.90

自引率

2.10%

发文量

123

审稿时长

1.5 months

期刊介绍： Biotechnology Journal (2019 Journal Citation Reports: 3.543) is fully comprehensive in its scope and publishes strictly peer-reviewed papers covering novel aspects and methods in all areas of biotechnology. Some issues are devoted to a special topic, providing the latest information on the most crucial areas of research and technological advances. In addition to these special issues, the journal welcomes unsolicited submissions for primary research articles, such as Research Articles, Rapid Communications and Biotech Methods. BTJ also welcomes proposals of Review Articles - please send in a brief outline of the article and the senior author''s CV to the editorial office. BTJ promotes a special emphasis on: Systems Biotechnology Synthetic Biology and Metabolic Engineering Nanobiotechnology and Biomaterials Tissue engineering, Regenerative Medicine and Stem cells Gene Editing, Gene therapy and Immunotherapy Omics technologies Industrial Biotechnology, Biopharmaceuticals and Biocatalysis Bioprocess engineering and Downstream processing Plant Biotechnology Biosafety, Biotech Ethics, Science Communication Methods and Advances.