Immunity Gone Viral: Subacute Cognitive Decline With Multifocal Brain Lesions in Neuromyelitis Optica Spectrum Disorder.

IF 8 1区医学 Q1 CLINICAL NEUROLOGY

Neurology® Neuroimmunology & Neuroinflammation Pub Date : 2026-07-01 Epub Date: 2026-06-23 DOI:10.1212/NXI.0000000000200607

Sonali Ajwani, Brian G Weinshenker, Caterina Giannini, Thomas M Habermann, Yucai Wang, Pamela Skrabek, Abedallah Balusha, Michel Toledano, Susan E Horsman, Claudia Francesca Lucchinetti, Eoin P Flanagan

引用次数: 0

Abstract

Subacute cognitive decline and imbalance in aquaporin-4-antibody-seropositive neuromyelitis optica spectrum disorder (AQP4+NMOSD) treated with mycophenolate has a broad differential diagnosis, including cerebral involvement of AQP4+NMOSD, infections, or other complications of immunosuppression. In this article, we highlight the diagnostic and treatment approach in a patient with AQP4+NMOSD who developed multifocal brain lesions.

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免疫病毒：亚急性认知能力下降与多灶性脑病变神经脊髓炎视谱障碍。

经霉酚酸盐治疗的水通道蛋白-4抗体血清阳性视神经脊髓炎谱系障碍（AQP4+NMOSD）的亚急性认知能力下降和失衡具有广泛的鉴别诊断，包括AQP4+NMOSD的脑受损伤、感染或其他免疫抑制并发症。在本文中，我们重点介绍了AQP4+NMOSD患者发生多灶性脑病变的诊断和治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology® Neuroimmunology & Neuroinflammation Neuroscience-Neurology

CiteScore

15.60

自引率

2.30%

发文量

219

审稿时长

8 weeks

期刊介绍： Neurology Neuroimmunology & Neuroinflammation is an official journal of the American Academy of Neurology. Neurology: Neuroimmunology & Neuroinflammation will be the premier peer-reviewed journal in neuroimmunology and neuroinflammation. This journal publishes rigorously peer-reviewed open-access reports of original research and in-depth reviews of topics in neuroimmunology & neuroinflammation, affecting the full range of neurologic diseases including (but not limited to) Alzheimer's disease, Parkinson's disease, ALS, tauopathy, and stroke; multiple sclerosis and NMO; inflammatory peripheral nerve and muscle disease, Guillain-Barré and myasthenia gravis; nervous system infection; paraneoplastic syndromes, noninfectious encephalitides and other antibody-mediated disorders; and psychiatric and neurodevelopmental disorders. Clinical trials, instructive case reports, and small case series will also be featured.