Clinicopathological characteristics of gastric papillary adenocarcinoma compared with tubular adenocarcinoma.

IF 6.1 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastric Cancer Pub Date : 2026-09-01 Epub Date: 2026-06-24 DOI:10.1007/s10120-026-01774-3

Taku Hattori, Masanori Terashima, Atsushi Ochiai, Tadakazu Shimoda, Yusuke Koseki, Kenichiro Furukawa, Keiichi Fujiya, Yutaka Tanizawa, Etsuro Bando

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引用次数: 0

Abstract

Background: Papillary adenocarcinoma (Pap) is a relatively rare histological subtype of differentiated adenocarcinoma, and its biological behavior has not been fully elucidated. The present study aimed to clarify the clinicopathological characteristics of Pap.

Methods: This study retrospectively included 1701 patients with differentiated-type gastric cancer who underwent gastrectomy at our institution between 2009 and 2021. Clinicopathological characteristics, recurrence patterns, and survival outcomes were compared between the two groups.

Results: Patients in the Pap group were older and showed higher rates of venous-and lymphatic invasion, as well as more advanced clinical and pathological stages. In the multivariate analysis of cumulative recurrence, histological type was identified as an independent predictor (HR 2.051, p = 0.037). The most common initial site of recurrence was the liver in both groups, with a significantly higher incidence observed in the Pap group (p < 0.001). In the multivariate analysis of overall survival, histological type was also identified as an independent prognostic factor (HR 1.962, p = 0.044).

Conclusions: Pap showed poorer survival than the Tub group, with a particularly higher incidence of liver metastasis recurrence.

查看原文本刊更多论文

胃乳头状腺癌与管状腺癌的临床病理特征比较。

背景：乳头状腺癌（Pap）是一种相对罕见的组织学亚型分化腺癌，其生物学行为尚未完全阐明。本研究旨在阐明Pap的临床病理特征。方法：本研究回顾性纳入2009年至2021年在我院行胃切除术的1701例分化型胃癌患者。比较两组患者的临床病理特征、复发模式和生存结果。结果：Pap组患者年龄较大，静脉和淋巴浸润率较高，临床和病理分期更晚。在累积复发的多变量分析中，组织学类型被确定为独立预测因子（HR 2.051, p = 0.037）。两组最常见的初始复发部位为肝脏，Pap组的发生率明显高于Tub组(p结论：Pap组的生存率低于Tub组，肝转移复发率特别高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastric Cancer 医学-胃肠肝病学

CiteScore

14.70

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.