Plasma Biomarkers for Alzheimer's Disease Across the Continuum: A Systematic Review of SIMOA-Based Studies.

IF 7.4 4区医学 Q3 CELL BIOLOGY

Cellular and Molecular Neurobiology Pub Date : 2026-06-24 DOI:10.1007/s10571-026-01752-4

María de Los Ángeles Fernández-Ceballos, José M Prieto-González, Roberto Carlos Agís-Balboa

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引用次数: 0

Abstract

Alzheimer's disease (AD) is the most common cause of dementia, and its overall incidence is rising as the proportion of older individuals in the population increases. Traditional diagnostic methods, such as lumbar puncture and neuroimaging, are costly and invasive, driving the search for blood-based biomarkers (BBB) for early diagnosis. The quantification of these biomarkers requires ultrasensitive techniques, such as the single-molecule array (SIMOA) platform. This systematic review synthesizes the available evidence on the biomarkers β-amyloid (Aβ42, Aβ40, and their ratio), tau protein (t-Tau, p-Tau181, p-Tau231, p-Tau217), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) in studies analyzing their blood concentrations using SIMOA, regardless of the platform model (SR-X, HD-1, HD-X). Findings support the potential of plasma biomarkers as an alternative or complement to invasive methods, although further validation is required before clinical implementation.

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阿尔茨海默病的血浆生物标志物：基于simoa研究的系统综述

阿尔茨海默病（AD）是痴呆症最常见的病因，随着人口中老年人比例的增加，其总体发病率也在上升。传统的诊断方法，如腰椎穿刺和神经成像，成本高且具有侵入性，这促使人们寻找基于血液的生物标志物（BBB）进行早期诊断。这些生物标记物的定量需要超灵敏的技术，如单分子阵列（SIMOA）平台。本系统综述综合了生物标志物β-淀粉样蛋白（a - β42， a - β40及其比值），tau蛋白（t-Tau, p-Tau181, p-Tau231, p-Tau217），神经丝轻链（NfL）和胶质纤维酸性蛋白（GFAP）在使用SIMOA分析其血液浓度的研究中的现有证据，无论平台模型（SR-X, HD-1, HD-X）如何。研究结果支持血浆生物标志物作为侵入性方法的替代或补充的潜力，尽管在临床实施之前需要进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular and Molecular Neurobiology 生物-神经科学

CiteScore

7.70

自引率

0.00%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.