Six-Month Real-World Data in Macular Edema Due to Retinal Vein Occlusion Treated with Faricimab: Swiss Retina Research Network Report.

IF 4.2 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2026-08-01 Epub Date: 2026-06-23 DOI:10.1007/s40123-026-01442-w

Katharina Heck, Katja Hatz, Marco Cattaneo, Isabel Pfister, Simon Magnin, Ludovico Ruscitti, Isabel Stasik, Anne Tillmann, Marat Shamshiev, Joseph Fang, Andreas Weinberger, Sandrine A Zweifel, Justus G Garweg, Chiara M Eandi, Gabriela Grimaldi, Marion R Munk, Gabor M Somfai, Aude Ambresin, Nicolas Feltgen

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引用次数: 0

Abstract

Introduction: Faricimab has been shown to be effective for treatment of macular edema (ME) due to retinal vein occlusion (RVO). So far, there is only limited evidence in real-life settings and hard-to-treat cases.

Methods: This multicenter, retrospective study evaluated patients with branch or central (including hemi-central) RVO treated with a faricimab treat-and-extend regimen with at least 6 months of follow-up (FU). Data included best-corrected visual acuity (BCVA), center-point retinal thickness (CRT), central subfield thickness (CST), presence of intra- and subretinal fluid in the 1, 3, and 6 mm Early Treatment Diabetic Retinopathy Study (ETDRS) grid zones, number of injections, and adverse events at baseline and at 1, 3-4, and 6 months of faricimab therapy. Pretreated eyes were additionally evaluated at predefined time points of the pretreatment period.

Results: A total of 112 eyes from 111 patients, including 13 treatment-naive and 99 pretreated eyes, were included. BCVA improved in treatment-naïve eyes from 0.46 ± 0.28 logarithm of the minimum angle of resolution (logMAR) at baseline to 0.32 ± 0.28 logMAR 6 months later (p = 0.041). BCVA remained stable in pretreated eyes (0.20 ± 0.25 vs. 0.21 ± 0.29 logMAR; p = 0.7). CRT and CST improved in both groups: in treatment-naïve eyes, CRT from 522 to 267 µm (p < 0.001) and CST from 467 to 301 µm (p = 0.032); in pretreated eyes, CRT from 275 to 253 µm (p = 0.009) and CST from 315 to 293 µm (p = 0.001). Significant resolution in retinal fluid was shown in the central 1 mm (p ≤ 0.014), 3 mm (p ≤ 0.013), and 6 mm zones (p ≤ 0.013) of the ETDRS grid in both groups. Over 6 months, treatment-naïve and pretreated eyes received a mean of 5 ± 1 injections. One systemic adverse event and no intraocular inflammation were recorded during FU.

Conclusion: This study demonstrates good real-world efficacy with significant drying and promising safety profile of faricimab in eyes with ME due to RVO, including a high proportion of hard-to-treat cases, over a 6-month period.

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法瑞昔单抗治疗视网膜静脉阻塞引起的黄斑水肿的六个月真实数据：瑞士视网膜研究网络报告。

Faricimab已被证明是有效的治疗黄斑水肿（ME）由于视网膜静脉阻塞（RVO）。到目前为止，在现实生活环境和难以治疗的病例中，只有有限的证据。方法：这项多中心、回顾性研究评估了接受法利西单抗治疗和延长方案治疗的分支或中央（包括半中心）RVO患者，随访时间至少为6个月。数据包括最佳矫正视力（BCVA）、中心点视网膜厚度（CRT）、中心亚野厚度（CST）、1、3和6 mm早期治疗糖尿病视网膜病变研究（ETDRS）网格区视网膜内和视网膜下液体的存在、注射次数以及基线和法利西单抗治疗1、3-4和6个月时的不良事件。另外在预处理期的预定时间点对预处理后的眼睛进行评估。结果：111例患者共纳入112只眼，其中未治疗13只眼，预处理99只眼。treatment-naïve眼的BCVA从基线时的0.46±0.28对数最小分辨角（logMAR）改善到6个月后的0.32±0.28对数最小分辨角（logMAR）（p = 0.041）。预处理眼的BCVA保持稳定（0.20±0.25 vs 0.21±0.29 logMAR; p = 0.7）。两组患者的CRT和CST均有改善：在treatment-naïve眼睛中，CRT从522µm降至267µm (p)。结论：该研究证明了faricimab在6个月期间对RVO引起的ME眼睛具有良好的实际疗效，具有显著的干燥性和有希望的安全性，包括高比例的难以治疗的病例。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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