Comparison of Single-Freezing Temperature-Guided and Conventional Time-to-Isolation-Guided Protocols of Cryoballoon in Atrial Fibrillation Ablation.

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Research Pub Date : 2026-06-05 eCollection Date: 2026-06-01 DOI:10.14740/cr2202

Xiao Yu Liu, Jie Zheng, Ku Lin Li, Hua Yan You, Shi Peng Dang, Yu Fei Dai, Hai Wei Geng, Yun Lai Gao, Ru Xing Wang

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Abstract

Background: The study aimed to compare the efficacy and safety of simplified single-freezing protocol with achieving -40 °C within 60 s of freezing as the observation index and the conventional time-to-isolation (TTI)-guided double-freezing protocol using second-generation cryoballoon in the treatment of atrial fibrillation (AF).

Methods: A retrospective analysis was performed. After propensity score matching, 146 patients who underwent conventional TTI-guided protocol freezing (conventional group) and 146 patients who underwent single-freezing temperature-guided protocol freezing (simplified group) using second-generation cryoballoon were included. Procedure time, X-ray time and dose, complications, success rate, and recurrence rate during follow-up were analyzed.

Results: Compared with the conventional group, the simplified group showed a significant reduction in procedure time (98.8 ± 16.3 vs. 79.4 ± 12.7 min, P < 0.001), and X-ray time (24.3 ± 6.8 vs. 17.8 ± 4.9 min, P < 0.001) and dose (681.1 ± 337.8 vs. 540.1 ± 343.7 mGy, P < 0.001). There was no significant difference in the success rate of acute pulmonary vein isolation between the two groups of patients (145/146 vs. 146/146, P = 0.975) and the proportion of maintaining sinus rhythm during follow-up (114/146 vs. 109/146, P = 0.842). Cox regression analysis showed that simplified protocol is not a predictive factor for recurrence in AF cryoablation.

Conclusions: In summary, the single-freezing temperature-guided protocol demonstrates comparable efficacy and safety to conventional TTI-guided protocol of second-generation cryoballoon in the AF ablation with the advantages of reducing procedure time and radiation exposure.

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低温球囊在房颤消融中单次冷冻温度引导与常规隔离时间引导方案的比较。

背景：本研究旨在比较以冷冻后60秒内达到-40°C为观察指标的简化单次冷冻方案与传统的第二代冷冻球囊在隔离时间（TTI）引导下的双次冷冻方案治疗心房颤动（AF）的疗效和安全性。方法：回顾性分析。经倾向评分匹配后，纳入146例采用常规tti引导方案冷冻的患者（常规组）和146例采用第二代冷冻球囊进行单次温度引导方案冷冻的患者（简化组）。分析手术时间、x线时间及剂量、并发症、成功率及复发率。结果：与常规组比较，简化组手术时间（98.8±16.3 vs. 79.4±12.7 min, P < 0.001）、x线时间（24.3±6.8 vs. 17.8±4.9 min, P < 0.001）和剂量（681.1±337.8 vs. 540.1±343.7 mGy, P < 0.001）均显著缩短。两组患者急性肺静脉隔离成功率（145/146比146/146，P = 0.975）及随访期间维持窦性心律比例（114/146比109/146，P = 0.842）差异无统计学意义。Cox回归分析显示简化方案不是房颤冷冻消融复发的预测因素。结论：综上所述，单冷冻温度引导方案在房颤消融中的疗效和安全性与传统tti引导的第二代冷冻球囊方案相当，具有缩短手术时间和减少辐射暴露的优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiology Research CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.