2092-P: Early Prevalence Shift from Type 1 towards Type 2 Diabetes across Adolescence and Young Adulthood with Marked Racial and Ethnic Differences: The PAPAYA Study

IF 9.3 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2026-06-11 DOI:10.2337/db26-2092-p

SHYLAJA SRINIVASAN, ANDREW KARTER, JENNIFER Y. LIU, CINDY J. HUANG, JULIA ACKER, SAHER DAREDIA, JULIANNA DEARDORFF, SONYA NEGRIFF, ALKA KANAYA, AI KUBO

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引用次数: 0

Abstract

Introduction and Objective: The growing burden of type 2 diabetes (T2D) in adolescents and young adults (AYAs) has highlighted changing diabetes patterns at younger ages. We determined changes in prevalence of type 1 diabetes (T1D) and T2D across the adolescent and young adult ages and examined differences across racial and ethnic groups. Methods: We analyzed 2024 electronic health record data from 783,801 AYAs aged 10-30 years with prevalent diabetes from Kaiser Permanente Northern California as part of the Predictors of Adverse Cardiometabolic Problems in Adolescents and Young Adults (PAPAYA) Study. Diabetes type was classified using a validated algorithm. We calculated the proportion of T1D and T2D cases by age and race/ethnicity across four age categories (10-15, 16-20, 21-25 and 26-30). Results: The prevalence of T1D and T2D among KPNC members aged 10-30 years was 4.32 and 6.56/1,000 respectively. Overall, T1D was more common than T2D (3.28 vs 1.04/1000) in early adolescence, but T2D increased steadily with age, becoming the more common type by ages 21-25 (T1D: 6.67 vs T2D: 4.97/1000) (Fig 1a). Earlier T2D predominance was evident in all non-White groups (Fig 1b-1i). Conclusion: In this diverse, real-world cohort, we observed an early and progressive relative rise in T2D that differed markedly by race and ethnicity. These findings underscore the need for screening and clinical strategies that reflect this shifting epidemiology. Disclosure S. Srinivasan: Research Support; Current; Abbott, Eli Lilly and Company. A. Karter: Research Support; Current; Dexcom, Inc. J.Y. Liu: None. C.J. Huang: None. J. Acker: None. S. Daredia: None. J. Deardorff: None. S. Negriff: None. A. Kanaya: None. A. Kubo: None. Funding National Institutes of Health (R01DK139116)

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2092-P：青少年和青年期从1型糖尿病到2型糖尿病的早期患病率转变具有显著的种族和民族差异：木瓜研究

简介和目的：青少年和青壮年（AYAs）中2型糖尿病（T2D）的负担日益增加，这突显了年轻一代糖尿病模式的变化。我们确定了1型糖尿病（T1D）和T2D在青少年和青年年龄段的患病率变化，并检查了种族和民族群体之间的差异。方法：作为青少年和年轻人不良心脏代谢问题预测因素（木瓜）研究的一部分，我们分析了783,801名年龄在10-30岁之间的糖尿病患者的2024年电子健康记录数据。使用经过验证的算法对糖尿病类型进行分类。我们按年龄和种族/民族计算了四个年龄组（10-15岁、16-20岁、21-25岁和26-30岁）中T1D和T2D病例的比例。结果：10 ~ 30岁KPNC成员T1D患病率为4.32 / 1000，T2D患病率为6.56/ 1000。总体而言，T1D在青春期早期比T2D更常见（3.28 vs 1.04/1000），但随着年龄的增长，T2D稳步增加，到21-25岁成为更常见的类型（T1D: 6.67 vs T2D: 4.97/1000）（图1a）。早期T2D优势在所有非白种人组中都很明显（图1b-1i）。结论：在这个多样化的现实世界队列中，我们观察到T2D的早期和渐进式相对上升，其种族和民族差异显著。这些发现强调需要筛查和临床策略来反映这种变化的流行病学。S. Srinivasan：研究支持；当前的;雅培，礼来公司。A.卡特：研究支持；当前的;, Dexcom公司将公司。J.Y. Liu：没有。C.J.黄：没有。阿克尔：没有。没有。J. Deardorff：没有。S.内格里夫：没有。答：没有。久保：没有。国家卫生研究院资助（R01DK139116）

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.