2075-P: Characterizing Total, Regional, and Ectopic Adipose Tissue Fat Content and Diabetes Risk Factors among Youth, Using Lancet Commission Obesity Definitions

IF 9.3 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2026-06-11 DOI:10.2337/db26-2075-p

MACY L. SHEPARD, ARMANDO PENA

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引用次数: 0

Abstract

Introduction and Objective: The field has yet to characterize cardiometabolic disease risk profiles in youth using new obesity definitions set by The Lancet Diabetes & Endocrinology Commission. We compared total, regional, and ectopic adipose tissue fat content & diabetes risk factors across obesity phenotypes in youth with BMI≥95th%. Methods: We used baseline data from the Preventing Diabetes in Latino Youth study that enrolled 117 Latino youth (12-16 y) with obesity (BMI≥95th%). Guided by the Commission’s definitions, we defined Clinical Obesity (CO) as excess body fat (boys>36%, girls>42%) measured by DXA with ≥3 metabolic risk factors; Preclinical Obesity (PO) as excess body fat with 0-2 risk factors; & No Obesity (NO) as having no excess body fat. Metabolic risk factors included glucose intolerance (fasting glucose 100-125 mg/dL, 2hr glucose 140-200 mg/dL, or HbA1c 5.7-6.4%), TRG≥110 mg/dL, HDL<40 mg/dL, & SBP or DBP>90th%. We compared total fat mass (FM) & lean mass (LM) using DXA; regional adipose tissue (subcutaneous abdominal [SAAT], visceral [VAT]) & ectopic fat depots (hepatic [HFF] & pancreatic fat fraction [PFF]) using MRI; insulin dynamics (HOMA-IR, Matsuda Index, insulin AUC, oral disposition index [oDI]); glucose regulation (1hr glucose, glucose AUC); and serum adiponectin [AD]. One-way ANOVA was analyzed (α = .05; Bonferroni post-hoc corrections). Results: The prevalence of CO, PO, and NO was 40% (N=47), 41% (N=48), & 19% NO (N=22), respectively. CO & PO showed significantly higher BMI%, waist circumference, FM, BF%, and SAAT (all p<0.05) but not VAT, HFF, or PFF compared to NO. CO demonstrated higher HOMA-IR and insulin AUC compared to PO & NO. CO had lower AD and oDI and higher LM, 1hr glucose, and fasting insulin versus NO. Conclusion: CO is distinguished from PO & NO by higher insulin resistance, beta cell dysfunction, and LM. CO and PO were distinguished by total and regional adiposity. New obesity definitions identify youth with greater cardiometabolic disease risk using sub-clinical markers. Disclosure M.L. Shepard: None. A. Pena: None.

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2075-P：使用《柳叶刀》委员会肥胖定义，确定青少年中总脂肪、区域和异位脂肪组织脂肪含量和糖尿病危险因素

前言和目的：该领域尚未使用柳叶刀糖尿病和内分泌学委员会制定的新肥胖定义来描述青少年心脏代谢疾病的风险概况。我们比较了BMI≥95%的青少年肥胖表型中总脂肪、区域脂肪和异位脂肪含量与糖尿病危险因素。方法：我们使用来自拉丁裔青年糖尿病预防研究的基线数据，该研究招募了117名肥胖（BMI≥95%）的拉丁裔青年（12-16岁）。在委员会定义的指导下，我们将临床肥胖（CO）定义为通过DXA测量的体脂过剩（男孩36%，女孩42%），伴有≥3个代谢危险因素；临床前肥胖（PO）为体脂过多，有0-2个危险因素；无肥胖（No）是指没有多余的身体脂肪。代谢危险因素包括葡萄糖耐受不良（空腹血糖100-125 mg/dL， 2小时血糖140-200 mg/dL，或HbA1c 5.7-6.4%）， TRG≥110 mg/dL, hdl & lt；40 mg/dL，舒张压或舒张压90%。我们使用DXA比较了总脂肪质量（FM）和瘦质量（LM）；局部脂肪组织（皮下腹部[SAAT]，内脏[VAT]）和异位脂肪库（肝脏[HFF]和胰腺脂肪部分[PFF]）；胰岛素动力学（HOMA-IR、Matsuda指数、胰岛素AUC、口腔处置指数[oDI]）；葡萄糖调节（1hr葡萄糖，葡萄糖AUC）；血清脂联素[AD]。单因素方差分析（α = 0.05； Bonferroni事后校正）。结果：CO、PO、NO患病率分别为40% （N=47）、41% （N=48）、19% （N=22）。与NO相比，CO &； PO的BMI%、腰围、FM、BF%和SAAT（均p < 0.05）显著高于CO &； p < 0.05)，但VAT、HFF和PFF无显著差异。与PO和NO相比，CO表现出更高的HOMA-IR和胰岛素AUC。与NO相比，CO具有较低的AD和oDI，较高的LM， 1hr葡萄糖和空腹胰岛素。结论：CO与PO和NO具有较高的胰岛素抵抗、β细胞功能障碍和LM。CO和PO以总肥胖和区域肥胖来区分。新的肥胖定义使用亚临床标记确定具有更大心脏代谢疾病风险的青年。谢泼德：没有。A.佩纳：没有。

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.