2093-P: HbA1c Trajectories and Risk of Impaired Glucose in Adolescents with Polycystic Ovarian Syndrome

IF 9.3 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2026-06-11 DOI:10.2337/db26-2093-p

KATRINA HOCH, KRISTEN CARLIN, ALISSA ROBERTS, BRYAN STRUB, ELAINE WALSH

{"title":"2093-P: HbA1c Trajectories and Risk of Impaired Glucose in Adolescents with Polycystic Ovarian Syndrome","authors":"KATRINA HOCH, KRISTEN CARLIN, ALISSA ROBERTS, BRYAN STRUB, ELAINE WALSH","doi":"10.2337/db26-2093-p","DOIUrl":null,"url":null,"abstract":"Introduction and Objective: Polycystic Ovarian Syndrome (PCOS) affects up to 12% of women of reproductive age and is associated with increased risk of insulin resistance and impaired glucose tolerance. This study evaluated baseline HbA1c levels and longitudinal HbA1c trajectories in adolescents with PCOS to identify characteristics associated with elevated or increasing HbA1c and to inform opportunities for enhanced screening and support. Methods: This retrospective cohort study used electronic health records from a free-standing pediatric hospital (January 2016-July 2025). Patients with a confirmed diagnosis of PCOS were included. Longitudinal HbA1c trajectories were evaluated using linear mixed-effects models with random intercepts and slopes, examining the impact of key demographic and clinical characteristics. Results: A total of 819 patients met inclusion criteria, with 0-7.2 years of follow-up. Mean HbA1c (5.4) across the population remained stable, but several factors were associated with increased HbA1c throughout the study period, including higher BMI (β=0.06, 95% CI=0.03, 0.09), older age at PCOS diagnosis (β=0.03, 95% CI=0.00, 0.05), Asian or unknown/declined race (β=0.18, 95% CI=0.05, 0.31 and β=0.25, 95% CI=0.04, 0.46, respectively) and acanthosis (β=0.18, 95% CI = 0.07, 0.28). Ethnicity moderated trajectories: HbA1c declined over time in non-Hispanic patients and increased in Hispanic patients (β=0.12, 95% CI=0.05, 0.20). Language also moderated patterns, with those with a language of care (LOC) of Spanish showing decreasing HbA1c relative to English and other LOC (β=-0.13, 95% CI=-0.23, -0.02). Conclusion: Early PCOS identification may help prevent rising HbA1c in higher-risk groups, including adolescents identifying as Asian or unknown/declined race. Patients from some groups may benefit from continued support after diagnosis. Language patterns suggest that culturally and linguistically aligned care may be protective for some patients. Disclosure K. Hoch: None. K. Carlin: None. A. Roberts: None. B. Strub: None. E. Walsh: None. Funding Lenssen Grant for Nutrition Research at Seattle Children's Research Institute","PeriodicalId":11376,"journal":{"name":"Diabetes","volume":"46 1","pages":""},"PeriodicalIF":9.3000,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2337/db26-2093-p","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction and Objective: Polycystic Ovarian Syndrome (PCOS) affects up to 12% of women of reproductive age and is associated with increased risk of insulin resistance and impaired glucose tolerance. This study evaluated baseline HbA1c levels and longitudinal HbA1c trajectories in adolescents with PCOS to identify characteristics associated with elevated or increasing HbA1c and to inform opportunities for enhanced screening and support. Methods: This retrospective cohort study used electronic health records from a free-standing pediatric hospital (January 2016-July 2025). Patients with a confirmed diagnosis of PCOS were included. Longitudinal HbA1c trajectories were evaluated using linear mixed-effects models with random intercepts and slopes, examining the impact of key demographic and clinical characteristics. Results: A total of 819 patients met inclusion criteria, with 0-7.2 years of follow-up. Mean HbA1c (5.4) across the population remained stable, but several factors were associated with increased HbA1c throughout the study period, including higher BMI (β=0.06, 95% CI=0.03, 0.09), older age at PCOS diagnosis (β=0.03, 95% CI=0.00, 0.05), Asian or unknown/declined race (β=0.18, 95% CI=0.05, 0.31 and β=0.25, 95% CI=0.04, 0.46, respectively) and acanthosis (β=0.18, 95% CI = 0.07, 0.28). Ethnicity moderated trajectories: HbA1c declined over time in non-Hispanic patients and increased in Hispanic patients (β=0.12, 95% CI=0.05, 0.20). Language also moderated patterns, with those with a language of care (LOC) of Spanish showing decreasing HbA1c relative to English and other LOC (β=-0.13, 95% CI=-0.23, -0.02). Conclusion: Early PCOS identification may help prevent rising HbA1c in higher-risk groups, including adolescents identifying as Asian or unknown/declined race. Patients from some groups may benefit from continued support after diagnosis. Language patterns suggest that culturally and linguistically aligned care may be protective for some patients. Disclosure K. Hoch: None. K. Carlin: None. A. Roberts: None. B. Strub: None. E. Walsh: None. Funding Lenssen Grant for Nutrition Research at Seattle Children's Research Institute

查看原文本刊更多论文

2093-P：青少年多囊卵巢综合征患者的糖化血红蛋白轨迹和血糖受损风险

简介和目的：多囊卵巢综合征（PCOS）影响多达12%的育龄妇女，并与胰岛素抵抗和糖耐量受损的风险增加有关。本研究评估了PCOS青少年患者的基线HbA1c水平和纵向HbA1c轨迹，以确定与HbA1c升高或增加相关的特征，并为加强筛查和支持提供机会。方法：本回顾性队列研究使用一家独立儿科医院（2016年1月- 2025年7月）的电子健康记录。确诊为多囊卵巢综合征的患者被纳入研究。使用随机截距和斜率的线性混合效应模型评估纵向HbA1c轨迹，检查关键人口统计学和临床特征的影响。结果：819例患者符合纳入标准，随访0 ~ 7.2年。整个人群的平均HbA1c（5.4）保持稳定，但在整个研究期间，有几个因素与HbA1c升高有关，包括较高的BMI (β=0.06, 95% CI=0.03, 0.09)， PCOS诊断时年龄较大（β=0.03, 95% CI=0.00, 0.05），亚洲或未知/下降的种族（β=0.18, 95% CI=0.05, 0.31和β=0.25, 95% CI=0.04, 0.46）和棘皮（β=0.18, 95% CI= 0.07, 0.28）。种族调节轨迹：非西班牙裔患者HbA1c随时间下降，西班牙裔患者HbA1c升高（β=0.12, 95% CI=0.05, 0.20）。语言也有调节模式，使用西班牙语（LOC）的患者HbA1c相对于使用英语和其他LOC的患者降低（β=-0.13, 95% CI=-0.23, -0.02）。结论：早期诊断PCOS可能有助于预防HbA1c升高的高危人群，包括亚洲或未知/衰落种族的青少年。某些群体的患者可能会从诊断后的持续支持中受益。语言模式表明，与文化和语言相一致的护理可能对一些患者有保护作用。K. Hoch：没有。卡林：没有。罗伯茨：没有。B.斯特鲁布：没有。沃尔什：没有。资助西雅图儿童研究所营养研究的Lenssen补助金

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.