{"title":"Evaluating Representation Embeddings from LLMs and Time-Series Foundation Models for Wearable Accelerometer-Based Health Prediction.","authors":"Soomin You, Tian Gu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Wearable accelerometer data capture rich behavioral signals relevant for personalized health, yet the comparative evidence on modern representation-learning approaches remains limited. Using accelerometer data from the National Health and Nutrition Examination Survey (NHANES), we evaluated three representation families for predicting multiple clinical outcomes: simple entropy-based features, pretrained large-language-model (LLM) embeddings, and time-series foundation model embeddings. Outcomes included overweight status, lipid biomarkers, glucose, arthritis, and cancers. Across all endpoints, entropy-based features consistently performed comparably to, and often slightly better than, embedding approaches. LLM-derived embeddings offered only marginal improvements (ΔAUC≈0.01-0.05), and time-series foundation model embeddings provided minimal value across varying sequence lengths. Prompt-based LLM reasoning performed worst (AUC≈0.56-0.65), demonstrating limited ability to infer quantitative physiological states from structured text. These results highlight the strength of simple variability features and underscore the need for domain-aligned pretraining in future time-series foundation models for health sensing.</p>","PeriodicalId":72181,"journal":{"name":"AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science","volume":"2026 ","pages":"564-573"},"PeriodicalIF":0.0000,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274337/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Wearable accelerometer data capture rich behavioral signals relevant for personalized health, yet the comparative evidence on modern representation-learning approaches remains limited. Using accelerometer data from the National Health and Nutrition Examination Survey (NHANES), we evaluated three representation families for predicting multiple clinical outcomes: simple entropy-based features, pretrained large-language-model (LLM) embeddings, and time-series foundation model embeddings. Outcomes included overweight status, lipid biomarkers, glucose, arthritis, and cancers. Across all endpoints, entropy-based features consistently performed comparably to, and often slightly better than, embedding approaches. LLM-derived embeddings offered only marginal improvements (ΔAUC≈0.01-0.05), and time-series foundation model embeddings provided minimal value across varying sequence lengths. Prompt-based LLM reasoning performed worst (AUC≈0.56-0.65), demonstrating limited ability to infer quantitative physiological states from structured text. These results highlight the strength of simple variability features and underscore the need for domain-aligned pretraining in future time-series foundation models for health sensing.