Correlates of serum thiamine levels among acute decompensated heart failure patients.

IF 0.7 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Journal of Africa Pub Date : 2026-02-20 DOI:10.5830/CVJA-2025-098

Busayo O Oguntola, Rasaq A Adebayo, Suraj A Ogunyemi, Tewogbade A Adedeji, Stephen O Oguntola, Olumide A Akinyele, Obafemi S Adesanya, Anthony O Akintomide

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引用次数: 0

Abstract

Background: Acute decompensated heart failure (ADHF) contributes adversely to health-related outcomes. Anorexia, early satiety, high metabolic rates, malnutrition, advanced age, and diuretic use characterise ADHF. This necessitated evaluating the correlates of low serum thiamine levels among ADHF patients in our facility.

Methods: This was a case-control study. One hundred and ten participants (55 AHF patients with 55 age and sex-matched healthy controls) were recruited consecutively. All participants had a physical examination, resting 12-lead ECG, 2D transthoracic echocardiography and baseline laboratory investigations and serum thiamine. Data analysis was done using STATA 13.1.

Results: The mean age of the study population was 45 (± 13.7) years. The mean serum thiamine levels among the ADHF and controls were 116.7 ± 31.6 nmol/L and 124.4 ± 29.8 nmol/L, respectively. Male gender, resting ECG QRS duration, and serum NT-proBNP independently predicted serum thiamine levels.

Conclusion: In this study, male gender, NT-proBNP and QRS duration independently predicted serum thiamine levels.

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急性失代偿性心力衰竭患者血清硫胺素水平的相关性。

背景：急性失代偿性心力衰竭（ADHF）对健康相关结局有不利影响。厌食、早饱、高代谢率、营养不良、高龄和使用利尿剂是ADHF的特征。这就有必要评估我们设施中ADHF患者血清硫胺素水平低的相关性。方法：采用病例-对照研究。110名参与者（55名AHF患者和55名年龄和性别匹配的健康对照）被连续招募。所有参与者均进行体格检查、静息12导联心电图、二维经胸超声心动图、基线实验室检查和血清硫胺素测定。数据分析采用STATA 13.1。结果：研究人群的平均年龄为45（±13.7）岁。ADHF组和对照组的平均血清硫胺素水平分别为116.7±31.6 nmol/L和124.4±29.8 nmol/L。男性、静息心电图QRS持续时间和血清NT-proBNP独立预测血清硫胺素水平。结论：在本研究中，男性性别、NT-proBNP和QRS持续时间独立预测血清硫胺素水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Journal of Africa CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Cardiovascular Journal of Africa (CVJA) is an international peer-reviewed journal that keeps cardiologists up to date with advances in the diagnosis and treatment of cardiovascular disease. Topics covered include coronary disease, electrophysiology, valve disease, imaging techniques, congenital heart disease (fetal, paediatric and adult), heart failure, surgery, and basic science.