Evidence- and Consensus-based European Guideline for Immunosuppressive Therapy After Pediatric Kidney Transplantation.

IF 4.9 2区医学 Q1 IMMUNOLOGY

Transplantation Pub Date : 2026-09-01 Epub Date: 2026-06-18 DOI:10.1097/TP.0000000000005772

Anna Grünewald, Thurid Ahlenstiel-Grunow, Zainab Arslan, Nina Battelino, Andreea-Liana Bot Rachisan, Antonia Bouts, Marco Busutti, Elisabeth Cornelissen, Huib de Jong, Jan Dudley, Ali Düzova, Fabian Eibensteiner, Alexander Fichtner, Svitlana Fomina, Mercedes Lopez Gonzalez, Bora Gulhan, Carl Grabitz, Julien Hogan, Britta Höcker, Stefanie Jeruschke, Nele Kanzelmeyer, Jon Jim Kim, Uwe Korst, Raffaela Labbadia, Mieczysław Litwin, Stephen Marks, Anette Melk, Gregor Novljan, Lukasz Obrycki, Jun Oh, Nils Pape, Andrea Pasini, Christian Patry, Martin Pohl, Evgenia Preka, Agnieszka Prytula, Susanne Rieger, Mario Schiffer, Raphael Schild, Tomas Seeman, Jelena Stojanovic, Sara Testa, Burkhard Tönshoff, Diletta Domenica Torres, Lutz T Weber, Monika Nothacker, Lars Pape

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引用次数: 0

Abstract

Background: There is a lack of robust evidence regarding immunosuppressive therapy in children and adolescents after kidney transplantation (KTx), and as such, international practice is highly variable. Recent clinical practice recommendations advocating individualized immunosuppressive strategies that incorporate newer agents are often not implemented. This can potentially contribute to reduced patient and renal allograft survival.

Methods: The guideline was developed between January 1, 2024, and December 12, 2025, according to the Guidance Manual of the German Association of Scientific Medical Societies by the German Societies for Pediatric Nephrology, Nephrology, Transplantation, and Pediatrics, the German Kidney Association, the International Pediatric Transplant Association, the European Society for Pediatric Nephrology and the Members of the Cooperative European Pediatric Renal Transplant Initiative.

Results: This evidence- and consensus-based guideline provides up-to-date, state-of-the-art recommendations for immunosuppressive therapy after KTx in pediatric kidney transplant recipients. It is based on the best available evidence and the consensus of the relevant German Medical Societies, Members of the Cooperative European Paediatric Renal Transplant Initiative, and the working group on transplantation of the European Society for Paediatric Nephrology, and the International Pediatric Transplant Association.

Conclusions: The formal consensus reached is particularly significant in cases of weak or inconclusive evidence and where recommendations are based solely on expert opinion.

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基于证据和共识的儿童肾移植后免疫抑制治疗欧洲指南。

背景：关于儿童和青少年肾移植（KTx）后免疫抑制治疗缺乏有力的证据，因此，国际惯例是高度可变的。最近的临床实践建议提倡个体化的免疫抑制策略，包括更新的药物往往没有实施。这可能会降低患者和移植肾的存活率。方法：该指南是在2024年1月1日至2025年12月12日期间根据德国科学医学学会协会指导手册制定的，由德国儿科肾脏学会、肾脏病学、移植和儿科学会、德国肾脏协会、国际儿科移植协会、欧洲儿科肾脏学会和欧洲儿科肾移植合作倡议成员共同制定。结果：这一基于证据和共识的指南为儿童肾移植受者KTx后的免疫抑制治疗提供了最新的、最先进的建议。它以现有的最佳证据和相关德国医学协会、欧洲儿科肾移植合作倡议成员、欧洲儿科肾病学会移植工作组和国际儿科移植协会的共识为基础。结论：在证据薄弱或不确定的情况下，以及在建议完全基于专家意见的情况下，达成正式共识尤其重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation 医学-免疫学

CiteScore

8.50

自引率

11.30%

发文量

1906

审稿时长

1 months

期刊介绍： The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation.