Effects of Donor Wage Reimbursement: Findings From the Living Donor Lost Wages Randomized Trial.

IF 4.9 2区 医学 Q1 IMMUNOLOGY
Transplantation Pub Date : 2026-10-01 Epub Date: 2026-06-18 DOI:10.1097/TP.0000000000005749
James R Rodrigue, Aaron Fleishman, Jesse D Schold, Martha Pavlakis, Amy R Evenson, Sarah Duncan, Didier A Mandelbrot, Prabhakar K Baliga
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引用次数: 0

Abstract

Background: Lost wages following living donation may deter patients from pursuing living donor kidney transplantation (LDKT) and potential donors from being evaluated.

Methods: We randomized patients undergoing transplant evaluation to 1 of 2 donor wage reimbursement groups ($1500 or $3000 maximum) and encouraged them to discuss this reimbursement program with their social network. These patients were compared with matched historical controls (HCs) on the likelihood of LDKT and ≥1 donor evaluation within 1 y of transplant evaluation. Multivariable logistic regression adjusted for demographic and clinical factors known to be associated with LDKT.

Results: Access to any donor wage reimbursement (lost wages $1500 maximum reimbursement and lost wages $3000 maximum reimbursement combined versus HC) was not significantly associated with LDKT occurrence (adjusted odds ratio [aOR], 0.85; 95% confidence interval [CI], 0.39-1.85; P  = 0.68) or with the likelihood of having at least 1 donor evaluated within 1 y of initial evaluation (aOR, 1.07; 95% CI, 0.76-1.50; P  = 0.70) after covariate adjustment. Also, donor wage reimbursement level (lost wages $1500 maximum reimbursement versus lost wages $3000 maximum reimbursement) was not associated with LDKT (aOR, 0.73; 95% CI, 0.22-2.44; P  = 0.61) or with having a donor evaluation initiated (aOR, 0.65; 95% CI, 0.40-1.05; P  = 0.11). In an exploratory analysis extending follow-up to account for COVID-related shutdowns, access to wage reimbursement was associated with higher odds of LDKT compared with HC (aOR, 2.16; 95% CI, 1.12-4.18; P  = 0.02).

Conclusions: Donor wage reimbursement, at the levels tested, did not increase LDKT or living donor evaluation likelihood in primary analyses, although exploratory findings suggest that effects may emerge with longer follow-up. Wage reimbursement alone may be insufficient to meaningfully expand LDKT.

供体工资补偿的影响:来自活体供体工资损失随机试验的结果。
背景:活体捐赠后的工资损失可能会阻止患者寻求活体肾脏移植(LDKT)和潜在捐赠者的评估。方法:我们将接受移植评估的患者随机分配到2个供体工资报销组(最高1500美元或3000美元)中的1个,并鼓励他们与他们的社会网络讨论这个报销计划。将这些患者与匹配的历史对照(HCs)进行比较,比较移植评估后1年内LDKT的可能性和≥1个供者评估。多变量逻辑回归校正了已知与LDKT相关的人口统计学和临床因素。结果:在协变量调整后,获得任何供体工资补偿(损失工资1500美元最高补偿和损失工资3000美元最高补偿与HC合并)与LDKT的发生(调整优势比[aOR], 0.85; 95%置信区间[CI], 0.39-1.85; P = 0.68)或至少1名供体在初始评估后1年内接受评估的可能性(aOR, 1.07; 95% CI, 0.76-1.50; P = 0.70)无显著相关性。此外,献血者工资补偿水平(损失工资1500美元最高补偿与损失工资3000美元最高补偿)与LDKT无关(aOR, 0.73; 95% CI, 0.22-2.44; P = 0.61),也与是否启动献血者评估无关(aOR, 0.65; 95% CI, 0.40-1.05; P = 0.11)。在一项探索性分析中,扩大随访以解释与covid相关的停工,与HC相比,获得工资报销与LDKT的几率更高相关(aOR, 2.16; 95% CI, 1.12-4.18; P = 0.02)。结论:在初步分析中,供体工资补偿,在测试的水平上,并没有增加LDKT或活体供体评估的可能性,尽管探索性研究结果表明,影响可能会随着随访时间的延长而出现。单靠工资补偿可能不足以有意地扩大LDKT。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Transplantation
Transplantation 医学-免疫学
CiteScore
8.50
自引率
11.30%
发文量
1906
审稿时长
1 months
期刊介绍: The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation. ​
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