Evaluation of the Effects of Bryonia multiflora Extract in a Chemically Induced Rat Breast Cancer Model.

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL

Anti-cancer agents in medicinal chemistry Pub Date : 2026-06-16 DOI:10.2174/0118715206476039260531171134

Özgür Aslan, Ayhan Yıldırım, Mehmet Hanifi Durak

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引用次数: 0

Abstract

Introduction: To evaluate the effects of dietary Bryonia multiflora Boiss. & Heldr. (B. multiflora) Extract, a rat breast cancer model was used that had been induced chemically with 7,12-dimethylbenz[a]anthracene (DMBA). In the study, haematological parameters, apoptosis markers (Bcl-2, Bax), and the protooncogene Her2 were evaluated.

Methods: The study involved 47 female Wistar albino rats, aged 12 -14 weeks. Seven rats were selected for the control group and ten rats for each of the tumour and three application groups.

Results: Statistically significant differences were found in terms of Bax between some pairs of groups. According to the Kruskal-Wallis results, statistically significant differences were found for Bax, MCV, MCH, MPV, and PDW (p < 0.05). However, the post-hoc Tamhane test revealed no significant differences between any of the groups (p > 0.05). Her-2 expression was detected in five rats (71.4%) in the control group and only in five rats (17.9%) in the tumour and plant extract groups.

Conclusion: Bax expression levels were lower in the tumour group and the B. multiflora extract-treated groups than in the control group. The absence of the apoptotic and/or cytotoxic effects observed in previous studies involving Bryonia species in this study may be due to several factors. Similar studies should be conducted in the future to further understand the various therapeutic effects of plants.

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何首乌提取物对化学诱导大鼠乳腺癌模型的作用评价。

前言：评价饲粮中添加多花苔藓的效果。& Heldr。采用7,12-二甲基苯[a]蒽（DMBA）化学诱导的大鼠乳腺癌模型（B. multiflora）提取物。在这项研究中，我们评估了血液学参数、细胞凋亡标志物（Bcl-2、Bax）和原癌基因Her2。方法：选取12 ~ 14周龄雌性Wistar白化大鼠47只。7只大鼠作为对照组，10只大鼠作为肿瘤组和3个应用组。结果：部分组间Bax值差异有统计学意义。根据Kruskal-Wallis结果，Bax、MCV、MCH、MPV、PDW差异有统计学意义（p < 0.05）。然而，事后Tamhane检验显示各组之间没有显著差异（p < 0.05）。对照组有5只大鼠（71.4%）表达Her-2，肿瘤组和植物提取物组仅有5只大鼠（17.9%）表达Her-2。结论：肿瘤组和多连草提取物处理组Bax表达水平低于对照组。在本研究中，未观察到先前涉及苔藓虫物种的研究中观察到的凋亡和/或细胞毒性作用，可能是由于以下几个因素。今后应进行类似的研究，以进一步了解植物的各种治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL

CiteScore

5.10

自引率

3.60%

发文量

323

审稿时长

4-8 weeks

期刊介绍： Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.