Is Generalized Joint Hypermobility a Risk Factor in the Development of Wrist Ganglion Cysts? A Retrospective Case-Control Study

IF 2.4 2区医学 Q2 ORTHOPEDICS

Journal of Hand Surgery-American Volume Pub Date : 2026-10-01 Epub Date: 2026-06-17 DOI:10.1016/j.jhsa.2026.05.007

Volkan Özel MD, İbrahim Halil Demir MD, Tuğrul Yıldırım MD

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引用次数: 0

Abstract

Purpose

The aim of this study was to evaluate the association between ganglion cysts and generalized joint hypermobility and to identify potential independent risk factors.

Methods

In this retrospective case-control study, a total of 972 participants were included, comprising 243 patients diagnosed with ganglion cysts and 729 controls. Demographic characteristics, body mass index, occupational category, regular physical activity, and Beighton scores were recorded. Generalized joint hypermobility was defined as a Beighton score ≥4. Risk factors were analyzed using univariate and multivariate logistic regression models.

Results

There were no significant differences between the groups in terms of age (P = .185), sex (P = .629), body mass index (P = .412), or regular physical activity (P = .423). The proportion of individuals engaged in manual occupations was significantly higher in the ganglion cyst group compared to controls (P = .005). The mean Beighton score was significantly greater in patients with ganglion cysts and the prevalence of hypermobility was 64% in the ganglion group compared with 19% in controls. In multivariate analysis, hypermobility (adjusted OR, 7.1; 95% CI: 5.1–9.9) and manual occupation (adjusted OR, 1.4; 95% CI: 1.0–1.9) were identified as independent risk factors. A significant positive trend was observed across Beighton score categories.

Conclusions

Generalized joint hypermobility seems to be a strong and independent risk factor for the development of ganglion cysts. The risk increases substantially with greater severity of hypermobility. These findings suggest that intrinsic connective tissue characteristics may play a key role in the pathogenesis of ganglion cysts.

Type of study/level of evidence

Aetiology (risk factors) III.

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广泛性关节活动过度是腕神经节囊肿发生的危险因素吗？回顾性病例对照研究。

目的：本研究的目的是评估神经节囊肿与广泛性关节过度活动之间的关系，并确定潜在的独立危险因素。方法：在本回顾性病例对照研究中，共纳入972名参与者，其中243名诊断为神经节囊肿的患者和729名对照组。记录人口统计学特征、体重指数、职业类别、定期体育活动和Beighton评分。广义关节活动过度被定义为Beighton评分≥4。使用单因素和多因素logistic回归模型分析危险因素。结果：两组患者在年龄（P = 0.185）、性别（P = 0.629）、体重指数（P = 0.412）、常规体力活动（P = 0.423）等方面无显著差异。神经节囊肿组从事体力劳动的个体比例显著高于对照组（P = 0.005）。神经节囊肿患者的平均Beighton评分明显更高，神经节囊肿组的过度活动率为64%，而对照组为19%。在多变量分析中，过度活动（调整后的OR， 7.1; 95% CI: 5.1-9.9）和体力劳动（调整后的OR， 1.4; 95% CI: 1.0-1.9）被确定为独立的危险因素。在贝顿评分类别中观察到显著的正趋势。结论：广泛性关节过度活动似乎是神经节囊肿发展的一个强大而独立的危险因素。这种风险随着过度活动的严重程度而显著增加。这些发现表明，内在结缔组织特征可能在神经节囊肿的发病机制中起关键作用。研究类型：病因学（危险因素），病例对照研究。证据等级：三级。

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来源期刊

Journal of Hand Surgery-American Volume 医学-外科

CiteScore

3.20

自引率

10.50%

发文量

402

审稿时长

12 weeks

期刊介绍： The Journal of Hand Surgery publishes original, peer-reviewed articles related to the pathophysiology, diagnosis, and treatment of diseases and conditions of the upper extremity; these include both clinical and basic science studies, along with case reports. Special features include Review Articles (including Current Concepts and The Hand Surgery Landscape), Reviews of Books and Media, and Letters to the Editor.