Neuro-axonal injury biomarker serum neurofilament light chain is associated with osteoarthritis: a dual-cohort study from NHANES and UK Biobank.

IF 4.3 3区医学 Q1 PATHOLOGY

Expert Review of Molecular Diagnostics Pub Date : 2026-07-01 Epub Date: 2026-06-17 DOI:10.1080/14737159.2026.2690188

Mingxuan Liu, Huade Ma, Haidong Zhou, Kangqi Xie, Changtai Luo, Zhonglong He, Zhongxing Ning, Jihua Wei, Dianbo Yu

{"title":"Neuro-axonal injury biomarker serum neurofilament light chain is associated with osteoarthritis: a dual-cohort study from NHANES and UK Biobank.","authors":"Mingxuan Liu, Huade Ma, Haidong Zhou, Kangqi Xie, Changtai Luo, Zhonglong He, Zhongxing Ning, Jihua Wei, Dianbo Yu","doi":"10.1080/14737159.2026.2690188","DOIUrl":null,"url":null,"abstract":"Background: Osteoarthritis (OA) affects over half a billion people globally, representing a major public health burden. Serum neurofilament light chain (sNFL) has recently been implicated in systemic inflammation and metabolic disorders.Research design and methods: This dual-cohort study analyzed data from the National Health and Nutrition Examination Survey (NHANES) and the UK Biobank. In NHANES, sNFL was measured via a high-sensitivity immunoassay, while in UKB, NfL was quantified using the Olink Explore 3072 proteomics platform. OA was defined by self-report in NHANES, and a combination of self-report and ICD-10 hospital records in UKB. The associations were evaluated using multivariate logistic regression and RCS.Results: Higher sNFL levels were significantly associated with increased OA odds in both cohorts. In fully adjusted models, each 1-unit increase in log-transformed sNFL corresponded to 85% higher odds in NHANES [OR = 1.85, 95% CI: (1.51, 2.23)] and 28% higher odds in UKB [OR = 1.28, 95% CI: (1.21, 1.36)]. Comparing the highest to lowest quartiles, ORs were 4.41 (95% CI: 2.71, 7.13) and 1.46 (95% CI: 1.34, 1.59), respectively (both p for trend <0.01).Conclusions: Elevated sNFL levels are independently and consistently associated with a higher prevalence of OA across two distinct national cohorts.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"633-641"},"PeriodicalIF":4.3000,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Molecular Diagnostics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14737159.2026.2690188","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/17 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Osteoarthritis (OA) affects over half a billion people globally, representing a major public health burden. Serum neurofilament light chain (sNFL) has recently been implicated in systemic inflammation and metabolic disorders.

Research design and methods: This dual-cohort study analyzed data from the National Health and Nutrition Examination Survey (NHANES) and the UK Biobank. In NHANES, sNFL was measured via a high-sensitivity immunoassay, while in UKB, NfL was quantified using the Olink Explore 3072 proteomics platform. OA was defined by self-report in NHANES, and a combination of self-report and ICD-10 hospital records in UKB. The associations were evaluated using multivariate logistic regression and RCS.

Results: Higher sNFL levels were significantly associated with increased OA odds in both cohorts. In fully adjusted models, each 1-unit increase in log-transformed sNFL corresponded to 85% higher odds in NHANES [OR = 1.85, 95% CI: (1.51, 2.23)] and 28% higher odds in UKB [OR = 1.28, 95% CI: (1.21, 1.36)]. Comparing the highest to lowest quartiles, ORs were 4.41 (95% CI: 2.71, 7.13) and 1.46 (95% CI: 1.34, 1.59), respectively (both p for trend <0.01).

Conclusions: Elevated sNFL levels are independently and consistently associated with a higher prevalence of OA across two distinct national cohorts.

查看原文本刊更多论文

神经轴突损伤生物标志物血清神经丝轻链与骨关节炎相关：来自NHANES和UK biobank的双队列研究

背景：骨关节炎（OA）影响全球超过5亿人，是一个主要的公共卫生负担。血清神经丝轻链（sNFL）最近被认为与全身性炎症和代谢紊乱有关。研究设计和方法：这项双队列研究分析了来自国家健康和营养检查调查（NHANES）和英国生物银行的数据。在NHANES中，sNFL通过高灵敏度免疫分析法进行测量，而在UKB中，NfL使用Olink Explore 3072蛋白质组学平台进行量化。OA在NHANES中由自我报告定义，在UKB中由自我报告和ICD-10医院记录相结合定义。使用多变量逻辑回归和RCS对相关性进行评估。结果：在两个队列中，较高的sNFL水平与OA发生率增加显著相关。在完全调整后的模型中，log-transformed sNFL每增加1个单位，NHANES的发生率增加85% [OR = 1.85, 95% CI: (1.51, 2.23)]， UKB的发生率增加28% [OR = 1.28, 95% CI:(1.21, 1.36)]。比较最高和最低四分位数，or分别为4.41 （95% CI: 2.71, 7.13）和1.46 (95% CI: 1.34, 1.59) （P均为趋势）。结论：在两个不同的国家队列中，sNFL水平升高与OA患病率升高独立且一致相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Expert Review of Molecular Diagnostics 医学-病理学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.