High-resolution PET detectors with dual-ended readout using cost-effective highly multiplexed readout circuit and MPT2321 ASIC.

IF 3.5 2区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

EJNMMI Physics Pub Date : 2026-06-15 DOI:10.1186/s40658-026-00908-x

Zhiqiang Zhu, Denghong Ren, Weiming Chen, Wei Shen, Xianchao Huang, Ning Ren, Zhonghua Kuang, Zhanli Hu, Yongfeng Yang, Zheng Liu

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引用次数: 0

Abstract

Background: Small-animal positron emission tomography (PET) imaging is commonly employed in biomedical research to accelerate the translation of the discovery in the fields of molecular and cellular biology into the clinical practice. Its performance and cost are largely dependent on the employed detectors and electronics. In this work, a new electronics scheme aiming to simplify PET electronics is evaluated using two dual-ended readout PET detectors with high spatial resolution.

Methods: The first detector is composed of a 16 × 16 lutetium-yttrium oxyorthosilicate (LYSO) array with crystal dimensions of 1.45 × 1.45 × 20 mm³. The second detector is composed of a 26 × 26 LYSO array with crystal dimensions of 0.75 × 0.75 × 20 mm³. Both LYSO arrays are dual-ended read out by 8 × 8 Hamamatsu S14161-3050HS-08 silicon photomultiplier (SiPM) arrays with a sensitive pixel area of 3 × 3 mm² and a pitch of 3.2 mm. The 64 outputs of the SiPM array are read out by a highly multiplexed row-column summation network to convert them to four position-encoded energy signals. The four signals are processed by a commercial 32-channel MPT2321 ASIC. The flood map, energy resolution, depth of interaction (DOI) resolution, and timing resolution of the detectors are measured.

Results: The first detector provided a flood map with all crystals resolved and an average peak-to-valley ratio (PVR) of 3.59 was obtained for the flood map quality, an energy resolution of 14.2 ± 0.4%, a DOI resolution of 3.04 ± 0.37 mm and a detector timing resolution (DTR) of 2.24 ± 0.10 ns. The second detector provided a flood map with all crystals resolved and an average PVR of 2.61 was obtained, an energy resolution of 15.3 ± 0.7%, a DOI resolution of 2.56 ± 0.46 mm and a DTR of 2.38 ± 0.20 ns.

Conclusion: The electronics scheme evaluated in this study provides competitive energy and DOI performance for high-resolution small-animal PET detectors while significantly reducing electronics channel count and system complexity.

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高分辨率PET检测器与双端读出采用高性价比的高复用读出电路和MPT2321 ASIC。

背景：小动物正电子发射断层扫描（PET）成像通常用于生物医学研究，以加速分子和细胞生物学领域的发现转化为临床实践。它的性能和成本在很大程度上取决于所使用的探测器和电子设备。在这项工作中，使用两个具有高空间分辨率的双端读出PET检测器来评估旨在简化PET电子的新电子方案。方法：第一个探测器由晶体尺寸为1.45 × 1.45 × 20 mm³的16 × 16氧化硅酸镥钇（LYSO）阵列组成。第二个探测器由26 × 26 LYSO阵列组成，晶体尺寸为0.75 × 0.75 × 20 mm³。两种LYSO阵列均采用8 × 8 Hamamatsu S14161-3050HS-08硅光电倍增管（SiPM）阵列双端读出，敏感像素面积为3 × 3 mm2，间距为3.2 mm。SiPM阵列的64个输出由高度复用的行列求和网络读出，以将其转换为四个位置编码的能量信号。这四个信号由商用32通道MPT2321 ASIC处理。测量了探测器的洪水图、能量分辨率、相互作用深度（DOI）分辨率和时序分辨率。结果：第一种探测器提供了全部晶体分辨率的洪水图，洪水图质量的平均峰谷比（PVR）为3.59，能量分辨率为14.2±0.4%，DOI分辨率为3.04±0.37 mm，探测器时间分辨率（DTR）为2.24±0.10 ns。第二个探测器提供了所有晶体分辨率的洪水图，平均PVR为2.61，能量分辨率为15.3±0.7%，DOI分辨率为2.56±0.46 mm， DTR为2.38±0.20 ns。结论：本研究评估的电子方案为高分辨率小动物PET探测器提供了具有竞争力的能量和DOI性能，同时显着减少了电子通道数和系统复杂性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EJNMMI Physics Physics and Astronomy-Radiation

CiteScore

6.70

自引率

10.00%

发文量

审稿时长

13 weeks

期刊介绍： EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.