{"title":"Chronobiomaterials for circadian-aligned brain therapeutics.","authors":"Shubham Garg, Burgundy Walters, Diego C Fernandez","doi":"10.1016/j.tips.2026.05.005","DOIUrl":null,"url":null,"abstract":"<p><p>Circadian rhythms are endogenous ~24 h oscillations that regulate daily changes in neural activity, metabolism, and behavior. Disruption of circadian rhythms is a hallmark of neurological and psychiatric disorders, yet most brain-directed therapies use fixed dosing schedules that do not account for time-of-day variations in drug efficacy and toxicity. Recent advances in bioengineering have led to the development of chronobiomaterials-including nanoparticles, exosomes, hydrogels, cell-based systems, and bioelectronic interfaces-that enable programmable and temporally precise control of therapeutic delivery. Here, we describe the multiscale organization of cellular and molecular circadian clocks in the brain, review chronobiomaterial platforms designed to modulate circadian phase, amplitude, and period, and discuss AI-enabled closed-loop approaches for personalized chronotherapy.</p>","PeriodicalId":23250,"journal":{"name":"Trends in pharmacological sciences","volume":" ","pages":"802-815"},"PeriodicalIF":24.0000,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in pharmacological sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tips.2026.05.005","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/12 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Circadian rhythms are endogenous ~24 h oscillations that regulate daily changes in neural activity, metabolism, and behavior. Disruption of circadian rhythms is a hallmark of neurological and psychiatric disorders, yet most brain-directed therapies use fixed dosing schedules that do not account for time-of-day variations in drug efficacy and toxicity. Recent advances in bioengineering have led to the development of chronobiomaterials-including nanoparticles, exosomes, hydrogels, cell-based systems, and bioelectronic interfaces-that enable programmable and temporally precise control of therapeutic delivery. Here, we describe the multiscale organization of cellular and molecular circadian clocks in the brain, review chronobiomaterial platforms designed to modulate circadian phase, amplitude, and period, and discuss AI-enabled closed-loop approaches for personalized chronotherapy.
期刊介绍：
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
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