Therapeutic Effects of Hemoperfusion in Treating Long-Acting Anticoagulant Rodenticide Poisoning.

IF 2.2 3区医学 Q3 HEMATOLOGY

Blood Purification Pub Date : 2026-06-12 DOI:10.1159/000552075

Jianguang Dong, Bingling Yin, Jieyi Wu, Xiaobo Peng, Xiaoxia Lu, Zhongying Liu, Haojun Fan, Yanmei Zhao, Ziquan Liu, Zewu Qiu, Qiang Wen, Zhiguo Pan, Guodong Lin

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Abstract

Introduction: Second-generation anticoagulant rodenticides often cause severe bleeding that can be life threatening and have limited effective treatment options. This study aimed to evaluate the therapeutic efficacy of hemoperfusion in patients with rodenticide poisoning.

Methods: We retrospectively analyzed data of 148 patients diagnosed with rodenticide poisoning at the Fifth Medical Center of the Chinese PLA General Hospital (China) between 2014 and 2021. The patients were divided into hemoperfusion and non-hemoperfusion groups based on whether or not they had received blood purification treatment. We compared clinical characteristics, serum drug concentrations, durations of hospital stay, and durations of vitamin K1 (VK1) therapy between the two groups using univariate and multivariate analyses. Subgroup analyses were also conducted to assess the effect of hemoperfusion in patients poisoned with brodifacoum and bromadiolone.

Results: Of 148 screened patients, 115 patients were included (hemoperfusion [n = 24] and non-hemoperfusion [n = 91]). The rate of blood toxin clearance per unit time may have been faster in the hemoperfusion group. Subgroup analyses revealed that hemoperfusion significantly reduced the duration of VK1 therapy in patients poisoned with brodifacoum (p = 0.044).

Conclusion: Hemoperfusion effectively reduced serum rodenticide concentrations in patients with poisoning. Moreover, hemoperfusion can reduce the duration of VK1 therapy in patients poisoned by brodifacoum.

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血液灌流治疗长效抗凝剂杀鼠剂中毒的疗效观察。

第二代抗凝血灭鼠剂通常会导致危及生命的严重出血，并且有效的治疗选择有限。本研究旨在评价血液灌流治疗杀鼠剂中毒的疗效。方法：回顾性分析2014 - 2021年在中国人民解放军总医院第五医疗中心诊断为杀鼠剂中毒的148例患者的资料。根据患者是否接受过血液净化治疗分为血液灌流组和非血液灌流组。我们使用单变量和多变量分析比较了两组患者的临床特征、血清药物浓度、住院时间和维生素K1 （VK1）治疗时间。还进行了亚组分析，以评估血液灌流对溴地考姆和溴地洛酮中毒患者的影响。结果：148例筛查患者中，纳入115例（血液灌流[n=24]，非血液灌流[n=91]）。单位时间内血液毒素清除率可能在血液灌流组更快。亚组分析显示，血液灌流显著缩短了布罗迪法乌姆中毒患者的VK1治疗时间（P=0.044）。结论：血液灌流可有效降低中毒患者血清杀鼠剂浓度。此外，血液灌流可缩短溴代醌中毒患者的VK1治疗时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Purification 医学-泌尿学与肾脏学

CiteScore

5.80

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Practical information on hemodialysis, hemofiltration, peritoneal dialysis and apheresis is featured in this journal. Recognizing the critical importance of equipment and procedures, particular emphasis has been placed on reports, drawn from a wide range of fields, describing technical advances and improvements in methodology. Papers reflect the search for cost-effective solutions which increase not only patient survival but also patient comfort and disease improvement through prevention or correction of undesirable effects. Advances in vascular access and blood anticoagulation, problems associated with exposure of blood to foreign surfaces and acute-care nephrology, including continuous therapies, also receive attention. Nephrologists, internists, intensivists and hospital staff involved in dialysis, apheresis and immunoadsorption for acute and chronic solid organ failure will find this journal useful and informative. ''Blood Purification'' also serves as a platform for multidisciplinary experiences involving nephrologists, cardiologists and critical care physicians in order to expand the level of interaction between different disciplines and specialities.