High-plasticity oncofetal cell states in early pre-metastatic colorectal cancer.

IF 56.1 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2026-07-13 Epub Date: 2026-06-11 DOI:10.1016/j.ccell.2026.05.011

Manon Bulliard, Yakov Perlov, Ömer H Yilmaz, Bing Shui

引用次数: 0

Abstract

In Nature, Buissant des Amorie et al. demonstrate that colorectal cancer acquires oncofetal cell states that resemble embryonic intestines, confer stem-like features, reshape epithelial identity, and prime cells for invasion and metastasis. Oncofetal cells are essential for metastasis and ubiquitous in non-metastatic tumors, with cancer-associated fibroblasts as key microenvironmental drivers.

查看原文本刊更多论文

早期转移前结直肠癌的高可塑性癌胎细胞状态。

在Nature杂志上，Buissant des Amorie等人证明，结直肠癌获得了类似于胚胎肠的癌胎细胞状态，赋予了干细胞样特征，重塑了上皮细胞的特性，并为侵袭和转移提供了原始细胞。癌胎细胞在转移中是必不可少的，在非转移性肿瘤中普遍存在，癌症相关成纤维细胞是关键的微环境驱动因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.