Caracterización de alteraciones capilaroscópicas en los pacientes con vasculitis sistémicas primarias

IF 1.5 Q4 RHEUMATOLOGY

Reumatologia Clinica Pub Date : 2026-06-01 Epub Date: 2026-05-08 DOI:10.1016/j.reuma.2026.502168

Everardo Álvarez-Hernández, Mariana Berenice Colli-Cortés

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引用次数: 0

Abstract

Background

Clinical manifestations in systemic vasculitis may be due to decreased arterial and venous flow because inflammation. There are few studies characterizing the changes in microcirculation in these diseases. Capillaroscopy can help detect changes in the microvasculature.

Objective

Characterize capillaroscopy alterations in primary systemic vasculitiśs patients and associated factors.

Patients

Cross-sectional, observational, and comparative study. Thirty-two patients with systemic vasculitis (PGA n = 17, PAM n = 4, AT n = 4, PHS n = 3, PAN n = 2, and others n = 2) and 32 controls matched for age and sex were included. All participants underwent capillaroscopy of eight fingers (2 nd to 5 th finger of each hand), obtaining at least two images of each finger studied for analysis.

Results

No characteristic pattern was found, only nonspecific changes. Avascular areas (84.4 vs. 59.4%, p = 0.026), microhemorrhages (34.4 vs. 6.3%, p < 0.005), and neoangiogenesis (34.4 vs. 0%, p < 0.001) were more frequent in the vasculitis group compared to the control group. The duration of the disease had moderate correlation with capillary density (r = −0.31, p = 0.010) and avascular areas (r = 0.40, p = 0.001).

cumulative damage (VDI) had moderate correlation (r = 0.50, p = 0.050) with capillary density. Capillary neoangiogenesis correlated with the diagnosis of vasculitis (r = −0.40, p = 0.001) and ischemic lesions (r = 0.371, p = 0.003). The factors associated with capillaroscopic changes were: disease activity (BVAS3), VDI and presence of ischemic lesions.

Discussion and conclusions

The search for capillaroscopic abnormalities in patients with systemic vasculitis may be useful in patients with a history of ischemic lesions and longer disease duration.

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原发性全身血管炎患者毛细血管镜改变的特征

背景：全身性血管炎的临床表现可能是由于炎症引起的动脉和静脉流量减少。很少有研究描述这些疾病的微循环变化。毛细血管镜检查有助于发现微血管系统的变化。目的探讨原发性系统性vasculitiśs患者的毛细血管镜检查改变及其相关因素。患者：横断面、观察性和比较研究。纳入32例全身性血管炎患者（PGA n = 17, PAM n = 4, AT n = 4, PHS n = 3, PAN n = 2，其他n = 2）和32例年龄和性别匹配的对照组。所有参与者都接受了8个手指（每只手的第2到第5个手指）的毛细血管镜检查，每个手指至少获得两张图像用于分析。结果无特征性变化，仅有非特异性变化。血管炎组无血管区（84.4比59.4%,p = 0.026）、微出血（34.4比6.3%,p < 0.005）和新生血管生成（34.4比0%，p < 0.001）比对照组更常见。疾病持续时间与毛细血管密度（r = - 0.31, p = 0.010）和无血管面积（r = 0.40, p = 0.001）有中度相关性。累积损伤（VDI）与毛细血管密度有中等相关性（r = 0.50, p = 0.050）。毛细血管新生与诊断血管炎（r = - 0.40, p = 0.001）和缺血性病变（r = 0.371, p = 0.003）相关。与毛细血管镜改变相关的因素是：疾病活动性（BVAS3）、VDI和缺血性病变的存在。讨论和结论在系统性血管炎患者中寻找毛细血管镜异常可能对有缺血性病变史和病程较长的患者有用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reumatologia Clinica RHEUMATOLOGY-

CiteScore

2.40

自引率

6.70%

发文量

105

审稿时长

54 days

期刊介绍： Una gran revista para cubrir eficazmente las necesidades de conocimientos en una patología de etiología, expresividad clínica y tratamiento tan amplios. Además es La Publicación Oficial de la Sociedad Española de Reumatología y del Colegio Mexicano de Reumatología y está incluida en los más prestigiosos índices de referencia en medicina.