Clinical Efficacy of Vitamin D Supplements for the Treatment of Anemia in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis

IF 1.4 4区医学 Q3 UROLOGY & NEPHROLOGY

Hemodialysis International Pub Date : 2026-07-09 Epub Date: 2026-06-07 DOI:10.1111/hdi.70078

Xiaodong Wanyan, Jiayun Xu

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引用次数: 0

Abstract

Objective

To conduct a meta-analysis of clinical randomized controlled studies related to vitamin D supplements for the treatment of anemia in patients with chronic kidney disease (CKD), to evaluate the clinical efficacy of vitamin D supplements for CKD patients complicated with anemia.

Methods

A literature review of the published literature in both English and Chinese was searched from the Cochrane Library, PubMed, Web of Science, CNKI and Wanfang Data that were published from the inception date to January 2018. Randomized controlled trials (RCTs) eligible for the inclusion and exclusion criteria were selected. The quality of eligible studies was assessed by the Cochrane Risk of Bias tool. Meta-analysis was performed by using Revman 5.3 software.

Results

A total of 12 RCTs comprising 779 patients were included in this meta-analysis, including 383 patients in the experimental group (with vitamin D supplementation) and 396 patients in the control group (without vitamin D supplementation). Meta-analysis showed that vitamin D supplements could significantly increase the hemoglobin (p < 0.01, SMD = 1.24, 95% CI: 1.02–1.45) and lower the dosage of erythropoietin required (p < 0.01, SMD = −0.76, 95% CI: −1.09 to −0.43).

Conclusion

Use of vitamin D supplements can significantly elevate the hemoglobin concentration and reduce the dosage of erythropoietin. However, these findings remain to be validated by large-scale, multi-center, prospective RCTs.

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维生素D补充剂治疗慢性肾病患者贫血的临床疗效：系统综述和荟萃分析

目的：对补充维生素D治疗慢性肾脏疾病（CKD）患者贫血相关临床随机对照研究进行meta分析，评价补充维生素D治疗CKD合并贫血的临床疗效。方法：检索Cochrane Library、PubMed、Web of Science、CNKI和万方数据，检索自项目成立之日至2018年1月已发表的中英文文献。选择符合纳入和排除标准的随机对照试验（RCTs）。通过Cochrane偏倚风险工具评估合格研究的质量。采用Revman 5.3软件进行meta分析。结果：本荟萃分析共纳入12项随机对照试验，共779例患者，其中实验组（补充维生素D） 383例，对照组（不补充维生素D） 396例。荟萃分析显示，补充维生素D可显著提高血红蛋白浓度(p)。结论：补充维生素D可显著提高血红蛋白浓度，降低促红细胞生成素用量。然而，这些发现仍有待大规模、多中心、前瞻性随机对照试验的验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hemodialysis International UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hemodialysis International was originally an annual publication containing the Proceedings of the International Symposium on Hemodialysis held in conjunction with the Annual Dialysis Conference. Since 2003, Hemodialysis International is published quarterly and contains original papers on clinical and experimental topics related to dialysis in addition to the Annual Dialysis Conference supplement. This journal is a must-have for nephrologists, nurses, and technicians worldwide. Quarterly issues of Hemodialysis International are included with your membership to the International Society for Hemodialysis. The journal contains original articles, review articles, and commentary to keep readers completely updated in the field of hemodialysis. Edited by international and multidisciplinary experts, Hemodialysis International disseminates critical information in the field.