{"title":"Unusual Infections following Haploidentical Hematopoietic Stem cell Transplant in a Case with severe Aplastic Anaemia'.","authors":"Manaswinee Mallik, Sarthak Wadhera, Sucheta Guleria, Harsimran Kaur, Valliappan Muthu, Sumeeta Khurana, Charanpreet Singh, Arihant Jain, Gaurav Prakash, Pankaj Malhotra, Alka Khadwal","doi":"10.31547/bct-2025-022","DOIUrl":null,"url":null,"abstract":"<p><p>We report a case of very severe aplastic anemia who developed from an uncommon bacterial, recalcitrant parasitic infection and viral reactivation after haploidentical hematopoietic stem cell transplant. The risk factors for multiple infections in this setting included immunocompromised state due to pretransplant prolonged immunosuppression, viral reactivation and graft-versus-host disease (GVHD) requiring multiple immunosuppressive agents. The index case was successfully treated for pulmonary nocardiosis, refractory giardiasis, cytomegalovirus, and adenovirus reactivation highlighting significant challenges during the management of underlying GVHD and these infections.</p>","PeriodicalId":72423,"journal":{"name":"Blood cell therapy","volume":"9 2","pages":"50-54"},"PeriodicalIF":0.0000,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237440/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Blood cell therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31547/bct-2025-022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/5/25 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
We report a case of very severe aplastic anemia who developed from an uncommon bacterial, recalcitrant parasitic infection and viral reactivation after haploidentical hematopoietic stem cell transplant. The risk factors for multiple infections in this setting included immunocompromised state due to pretransplant prolonged immunosuppression, viral reactivation and graft-versus-host disease (GVHD) requiring multiple immunosuppressive agents. The index case was successfully treated for pulmonary nocardiosis, refractory giardiasis, cytomegalovirus, and adenovirus reactivation highlighting significant challenges during the management of underlying GVHD and these infections.
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