Continuous erector spinae plane block for robotic-assisted thoracic surgery in lung cancer: a dual-center retrospective propensity-score weighted cohort study
Matheus Arraes, Sara Amaral, Saullo Queiroz Silveira, Leopoldo Muniz da Silva, Rafael Sousa Fava Nersessian, Francisco Jose Lucena Bezerra, Manoel de Souza Neto, Caroline Machado Nunes, Helidea de Oliveira Lima, Fernando Nardy Bellicieri, Glenio B. Mizubuti, Rafael Lombardi
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引用次数: 0
Abstract
Background
Postoperative analgesia remains challenging in thoracic surgery, particularly with the rise of Robotic-Assisted Thoracoscopic Surgery (RATS). The Erector Spinae Plane Block (ESPB) is a promising opioid-sparing technique, but its role in RATS is unclear.
Methods
In this retrospective dual-center cohort study, we included 78 patients with lung cancer undergoing RATS, who received general anesthesia with or without ESPB. ESPB involved a single shot of 30 mL of 0.5% ropivacaine injection at T7, followed by a 24-hour infusion of 0.2% ropivacaine (7 mL.h⁻¹). The primary outcome was opioid rescue within 36 hours. Secondary outcomes included hospital length of stay and chest tube duration. Confounders were balanced with Inverse Probability Treatment Weighting (IPTW).
Results
In unadjusted analyses, there was no significant difference in rescue opioid consumption between groups (ESPB 37.8% vs. GA 27.3%; p = 0.46). After propensity score weighting to improve covariate balance, ESPB use was associated with lower postoperative opioid requirements (OR = 0.57; 95% CI 0.32–0.79; p = 0.01). This finding may reflect improved adjustment for measured confounders, although residual confounding cannot be excluded. In contrast, chest tube presence within 24-hours was associated with higher opioid requirements (OR = 2.32; 95% CI 1.22–4.20; p = 0.04). ESPB patients also required fewer scheduled opioids during the first 24–36h postoperatively (p = 0.03).
Conclusion
In this observational cohort, ESPB use was associated with lower postoperative opioid requirements in RATS. These findings suggest a potential role for ESPB within ERAS pathways, although randomized studies are needed to confirm efficacy and define its role in minimally invasive thoracic surgery.
背景:在胸外科手术中,术后镇痛仍然具有挑战性,特别是随着机器人辅助胸腔镜手术(RATS)的兴起。直立脊柱平面阻滞(ESPB)是一种很有前途的阿片节约技术,但其在大鼠中的作用尚不清楚。方法:在这项回顾性双中心队列研究中,我们纳入了78例接受大鼠麻醉的肺癌患者,他们接受了全身麻醉,有或没有ESPB。ESPB包括在T7时单次注射30ml 0.5%罗哌卡因注射液,随后24小时输注0.2%罗哌卡因(7 mL.h⁻¹)。主要结局是36小时内阿片类药物抢救。次要结局包括住院时间和胸管时间。用逆概率处理加权(IPTW)平衡混杂因素。结果:在未经调整的分析中,两组间阿片类药物的急救消耗无显著差异(ESPB 37.8% vs. GA 27.3%; p = 0.46)。在倾向评分加权以改善协变量平衡后,ESPB的使用与术后阿片类药物需求降低相关(OR = 0.57;95% CI 0.32-0.79; p = 0.01)。这一发现可能反映了测量混杂因素调整的改善,尽管残留混杂因素不能排除。相比之下,24小时内存在胸管与更高的阿片类药物需求相关(OR = 2.32;95% CI 1.22-4.20; p = 0.04)。ESPB患者在术后24-36小时内需要较少的阿片类药物(p = 0.03)。结论:在这个观察性队列中,大鼠术后使用ESPB与较低的阿片类药物需求相关。这些发现表明ESPB在ERAS通路中的潜在作用,尽管需要随机研究来证实其疗效并确定其在微创胸外科手术中的作用。